Evidence map›Paper›PMID 42615931›Full record

ReviewThe European journal of neuroscience2026

Towards the Prevention of Freezing of Gait in Parkinson's Disease.

Anouk Tosserams, Jorik Nonnekes, Bastiaan R Bloem, Elbrich M Postma

Abstract readReview
In one paragraph

Review in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Towards the Prevention of Freezing of Gait in Parkinson's Disease.The European journal of neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anouk TosseramsDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Jorik NonnekesDepartment of Rehabilitation, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Bastiaan R BloemDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Elbrich M PostmaDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

ParkinsonNederland PR0230
6 · The paper itself

Abstract

Despite optimal management, freezing of gait (FOG) remains a disabling complication of Parkinson's disease (PD), contributing substantially to falls, loss of independence and reduced quality of life. This highlights the pressing need for a shift towards preventive approaches, aiming to postpone or even prevent its development. In this narrative review, we examine potential avenues for the secondary prevention of FOG. We discuss how FOG might be prevented specifically, by targeting modifiable risk factors that seem associated with the development of FOG. Examples of potentially effective strategies here include vascular prophylaxis and perhaps avoidance of pulsatile levodopa administration. Secondary prevention efforts also include generic disease-modifying strategies, including pleiotropic interventions such as exercise and nutrition, targeting either persons in the prodromal disease phase or persons with clinically manifest PD, who are still free from FOG. We conclude by discussing future avenues towards FOG prevention.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseAnimalsAntiparkinson AgentsHumansLevodopaRisk FactorsAntiparkinson AgentsLevodopadisease modificationfreezing of gaitlevodopaParkinson's diseasepreventionvascular prophylaxis

Identifiers

PMID42615931
PMCPMC13488605

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.