Evidence map›Paper›PMID 42616121›Full record

ReviewDie Ophthalmologie2026

[Real-time OCT-guided strategies for optimization of precision and safety in vitreoretinal surgery].

Paul Plettenberg, Salaheddin El Mourad, Siegfried Priglinger, Franziska Eckardt, Lars-Olof Hattenbach

Abstract readEnglish AbstractReview
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In one paragraph

Review in Die Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paul PlettenbergAugenklinik, Klinikum Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland. plettep@klilu.de.
Salaheddin El MouradAugenklinik, Klinikum Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland.
Siegfried PriglingerKlinik für Augenheilkunde, Ludwig-Maximilians-Universität München, München, Deutschland.
Franziska EckardtKlinik für Augenheilkunde, Ludwig-Maximilians-Universität München, München, Deutschland.
Lars-Olof HattenbachAugenklinik, Klinikum Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative real-time optical coherence tomography (iOCT) enables a dynamic visualization of retinal structures at the micrometer level during vitreoretinal surgery and provides additional information that can directly influence the course of surgery. The aim of this study is the presentation of the clinical utility, limitations and current evidence base for the use of iOCT in vitreoretinal surgery. MATERIAL AND

methodsA narrative review was conducted based on published studies, case series, subanalyses of prospective cohorts and systematic reviews addressing the use of iOCT in vitreoretinal procedures. The literature search was primarily performed using PubMed/MEDLINE.

resultsDuring epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling, iOCT can assist in identifying an appropriate initiation site for membrane peeling. It also enables real-time assessment of the tissue response and facilitates verification of complete membrane removal by detecting residual fragments. In macular hole surgery, iOCT enables intraoperative visualization of hole morphology and reliable assessment of ILM flap positioning, including after fluid-air exchange. In retinal detachment and proliferative vitreoretinopathy (PVR) surgery, iOCT not only facilitates the detection of residual subretinal fluid but also supports the evaluation of dissection planes and tractional membranes. DISCUSSION: Although many studies report a substantial added value of intraoperative OCT, a significant functional benefit, such as improvements in visual acuity outcomes, recurrence rates or complication rates has not yet been conclusively demonstrated. Nevertheless, the ability to dynamically assess retinal structures at micrometer resolution makes it possible to guide intraoperative decision-making, minimize iatrogenic tissue damage and enhance visualization, thereby providing a clear practical advantage, especially in complex cases or when microscopic visualization is limited. To date, limited evidence, high costs and heterogeneous technical implementations with variable clinical applicability have hindered widespread adoption of iOCT; however, in light of considerable technological advancements in recent years, increasing acceptance of this intraoperative imaging modality can be observed.

Indexed as

Retinal DiseasesSurgery, Computer-AssistedTomography, Optical CoherenceVitreoretinal SurgeryEpiretinal MembraneHumansEpiretinal gliosisintraoperativeMacular holeProliferative vitreoretinopathyRetinal detachment

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.