Evidence map›Paper›PMID 42616177›Full record

ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Cancer-related cognitive impairment in adult cancer survivors: a clinical practice review for healthcare providers.

Jashmira K Bhinder, Malika Peera, Samantha K F Kennedy, Nicolas H Hart, Darren Haywood, Muna Al-Khaifi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jashmira K BhinderFaculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Malika PeeraFaculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Samantha K F KennedyOdette Cancer Centre, Department of Family and Community Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Nicolas H HartFaculty of Health, Human Performance Research Centre, INSIGHT Research Institute, University of Technology Sydney (UTS), Sydney, NSW, Australia.
Darren Haywood *Faculty of Health, Human Performance Research Centre, INSIGHT Research Institute, University of Technology Sydney (UTS), Sydney, NSW, Australia.
Muna Al-Khaifi *Department of Surgery, Mount Sinai Hospital, Sinai Health System, Toronto, Canada. muna.alkhaifi@sinaihealth.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer-related cognitive impairment (CRCI) is a decline in cognitive function associated with cancer and its treatments, affecting approximately 60-75% of individuals with cancer. This review provides an evidence-based overview of the causes, assessment, and management of CRCI across the cancer continuum.

methodsA narrative literature review was conducted using peer-reviewed studies, clinical practice guidelines, systematic reviews, and expert consensus recommendations examining CRCI in adult cancer populations. The review focused on the biological and psychosocial contributors to CRCI, methods of assessment and diagnosis, and current evidence supporting pharmacological and non-pharmacological interventions.

resultsCRCI is a multifactorial condition associated with chemotherapy, endocrine therapy, radiotherapy, surgery, psychological distress, and lifestyle factors. Proposed mechanisms include neuroinflammation, oxidative stress, neurotoxicity, hormonal dysregulation, and psychosocial influences such as anxiety, depression, and fatigue. Assessment should incorporate both patient-reported cognitive concerns and objective neuropsychological testing, while also evaluating potentially reversible contributors including sleep disturbances, pain, medication effects, and emotional distress. Current evidence supports non-pharmacological interventions as first-line management, with physical activity and cognitive rehabilitation demonstrating the strongest benefits. Additional strategies including mindfulness-based interventions, psychoeducation, compensatory techniques, and healthy lifestyle modifications may further improve cognitive outcomes. Pharmacological therapies, including psychostimulants and neuroprotective agents, have shown inconsistent results and are not routinely recommended.

conclusionCRCI is a prevalent and clinically significant survivorship issue that requires greater recognition within oncology care. Routine screening, comprehensive assessment, and individualized management strategies can help mitigate cognitive symptoms and improve functional outcomes. Further research is needed to develop standardized screening tools, establish evidence-based treatment pathways, and improve integration of CRCI care into routine oncology practice.

Indexed as

Cancer SurvivorsCognitive DysfunctionNeoplasmsAdultCognitive TrainingHumansNeuropsychological TestsCancer-related cognitive impairmentCancer survivorshipCognitive dysfunctionCognitive rehabilitation

Identifiers

PMID42616177

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.