Evidence map›Paper›PMID 42616865›Full record

ArticleScience advances2026

A bacterial enzyme enhances both energy metabolism and health across the life span of

Yang Liu, Zhijuan Hu, Duo Duan, Lianfeng Wu, An-Ping Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang LiuSchool of Life Sciences, Fudan University, Shanghai, China.ORCID 0009-0001-1328-3287
Zhijuan HuCenter of Synthetic Biology and Integrated Bioengineering, Westlake University, Hangzhou, Zhejiang, China.ORCID 0009-0004-0571-0498
Duo DuanSchool of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.ORCID 0009-0003-9019-8056
Lianfeng WuCenter of Synthetic Biology and Integrated Bioengineering, Westlake University, Hangzhou, Zhejiang, China.ORCID 0000-0003-0237-2548
An-Ping ZengCenter of Synthetic Biology and Integrated Bioengineering, Westlake University, Hangzhou, Zhejiang, China.ORCID 0000-0001-9768-7096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The consequence of enhanced energy metabolism for health and life span of organisms is a fundamental yet controversially discussed issue of life and aging among others because of the fact that increasing energy metabolism often entails the risk of oxidative damage. To resolve this paradox, we introduce the bacterial-derived lipoic acid protein ligase A (LplA) as an orthogonal and defined molecular tool to enhance energy metabolism and at the same time to foster a low oxidative stress environment. Investigations in

Indexed as

Bacterial ProteinsCaenorhabditis elegansEnergy MetabolismLigasesLongevityAgingAnimalsHumansMiceOxidative StressBacterial ProteinsLigases

Identifiers

PMID42616865
PMCPMC13488889

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.