Evidence map›Paper›PMID 42616895›Full record

ArticleScience advances2026

Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic T

Jie Sun, Yali Lei, Huanhuan Yang, Shu Li, Bing Wu

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie SunDepartment of Urology, State Key Laboratory of Virology and Biosafety, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.ORCID 0009-0008-0207-9601
Yali LeiFrontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.ORCID 0009-0009-0393-2595
Huanhuan YangDepartment of Urology, State Key Laboratory of Virology and Biosafety, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.ORCID 0009-0005-0827-991X
Shu LiFrontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.ORCID 0000-0002-0007-5198
Bing WuDepartment of Urology, State Key Laboratory of Virology and Biosafety, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.ORCID 0000-0003-1656-3783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T helper 17 (T

Indexed as

Autoimmune DiseasesHydroxymethylglutaryl-CoA SynthaseTh17 CellsAnimalsCell DifferentiationEndoplasmic Reticulum StressEndoribonucleasesHumansMiceProtein Serine-Threonine KinasesEndoribonucleasesErn1 protein, mouseHydroxymethylglutaryl-CoA SynthaseProtein Serine-Threonine Kinases

Identifiers

PMID42616895
PMCPMC13488930

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.