Evidence map›Paper›PMID 42617270›Full record

ArticlePoultry science2026

Microbiota contributes to regulates the external genitalia development through gut-testis axis in male geese.

Yating Li, Qin Li, Xin Zhang, Yushi Wang, Guangliang Gao, Donghong Chen, Simeng Qin, Zhifu Cui, Lingbin Liu, Anfang Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yating LiCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China.
Qin LiChongqing Academy of Animal Sciences, Rongchang, Chongqing, 402460, China.
Xin ZhangChongqing Academy of Animal Sciences, Rongchang, Chongqing, 402460, China.
Yushi WangChongqing Academy of Animal Sciences, Rongchang, Chongqing, 402460, China.
Guangliang GaoChongqing Academy of Animal Sciences, Rongchang, Chongqing, 402460, China.
Donghong ChenCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China.
Simeng QinCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China.
Zhifu CuiCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China.
Lingbin LiuCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China.
Anfang LiuCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China.
Haiwei WangChongqing Academy of Animal Sciences, Rongchang, Chongqing, 402460, China.
Qigui WangChongqing Academy of Animal Sciences, Rongchang, Chongqing, 402460, China. Electronic address: wangqigui@hotmail.com.
Bincheng TangCollege of Animal Science and Technology, Southwest University, Beibei, Chongqing, 400715, China. Electronic address: i_cbtang@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Geese is one of the few poultry species with complete external genitalia, and the external genitalia abnormal development has become an important factor limiting the reproductive efficiency of the goose industry. Recent studies have shown that the gut microbiota plays an important role in regulating male reproductive processes, but its regulatory mechanisms in male geese's external genitalia development remain unclear. In this study, male geese with normal development (ND) and abnormal development (AD) external genitalia were selected as the research object, and multi-omics were used to investigate the regulatory of the microbe-mediated gut-testis axis on external genitalia development. At the transcriptomic level, we identified key DEGs (KNG1, P2RY4, SSTR5, and HRH3) in the testis and external genitalia between ND and AD groups, which were significantly enriched in the neuroactive ligand-receptor interaction pathway. Metabolomics analysis revealed that DMs in the ND and AD groups were significantly enriched in pathways related to aromatic amino acid metabolism and neural signal transduction. Furthermore, metagenomic results showed that the ND group was identified key bacterial genera g_Blautia and g_Faecousia affecting external genitalia development, which were associated with SCFAs synthesis and neuroendocrine signaling regulation. Integrated with multi-omics data, it was revealed that gut-derived neuroactive metabolic signals may participate in the molecular regulation of external genitalia development in male goose by modulating GPCRs signaling. Our findings not only provide new insights into the gut-testis axis regulates the development of external genitalia in male geese, but also contribute to improving the reproductive performance of male geese.

Indexed as

External genitaliaGooseGut microbiotaGut-testis axisMulti-omics

Identifiers

PMID42617270
PMCPMC13521025

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.