Evidence map›Paper›PMID 42617600›Full record

ArticleCell reports. Medicine2026

Humoral pregnancy analyses reveal strategies for fetal protection and aberrancy in miscarriage.

Brandon M Sie, Yumei Leng, Nadege Nziza, Moriah M Mitchell, Nicholas E Webb, Yunjoo Lee, Sunni L Mumford, Enrique F Schisterman, H Benjamin Larman, Boris Julg and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brandon M SieDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Yumei LengDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Nadege NzizaRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Moriah M MitchellDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Nicholas E WebbRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Yunjoo LeeRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Sunni L MumfordEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA; Departments of Biostatistics, Epidemiology, and Informatics, and Obstetrics and Gynecology Perelman School of Medicine, Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA.
Enrique F SchistermanDepartments of Biostatistics, Epidemiology, and Informatics, and Obstetrics and Gynecology Perelman School of Medicine, Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA.
H Benjamin LarmanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Boris JulgRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Galit AlterRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Stephen J ElledgeDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: selledge@genetics.med.harvard.edu.

Funding

NICHD NIH HHS HHSN275201100002CNICHD NIH HHS HHSN275201100002G
6 · The paper itself

Abstract

The maternal immune system must simultaneously defend against pathogens with tolerance of the antigenically distinct fetus. Despite the central importance of immune modulation during pregnancy, epitope-level analyses of the maternal antibody repertoire remain lacking. Here, we performed high-throughput, multi-isotype longitudinal serology of 119 women from preconception through pregnancy, combining phage display of linear peptides with whole protein-based antigen assays to profile antibody responses to viral and self-antigens. We observed a broad expansion of the maternal IgG repertoire and a relative increase in IgA titers, both tracking with pregnancy progression. These changes may augment transplacental and mucosal immunity in the fetus and newborn, respectively. Notably, pregnancies ending in miscarriage exhibited pronounced IgA titer spikes against both viral and self-antigens unrelated to active infection (sensitivity 14/19, 74%, specificity 95%), indicating an underlying immune perturbation may precede pregnancy loss.

Indexed as

Abortion, SpontaneousFetusImmunity, HumoralAdultAutoantigensFemaleHumansImmunoglobulin AImmunoglobulin GPregnancyAutoantigensImmunoglobulin AImmunoglobulin Gantibodyantibody repertoireHLAIgAIgGLuminexmiscarriagePhIP-seqpregnancy

Identifiers

PMID42617600
PMCPMC13589508

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.