Evidence map›Paper›PMID 42618682›Full record

ArticleMikrochimica acta2026

Combined SERS and chemometric analyses of blood plasma and bone marrow towards pediatric leukemia biomarkers detection.

Patrycja Wiewiórowska, Magdalena Wołowiec, Marta Czaplicka, Sylwia Magdalena Berus, Mateusz Pielach, Paweł Łaguna, Aneta Aniela Kowalska, Agnieszka Kamińska

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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrycja WiewiórowskaInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 01-224, Poland.ORCID http://orcid.org/0000-0002-5898-4159
Magdalena WołowiecDepartment and Clinic of Oncology, Pediatric Hematology, Clinical Transplantology and Pediatrics, Medical University of Warsaw, Warsaw, Poland.
Marta CzaplickaInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 01-224, Poland.ORCID http://orcid.org/0000-0003-3325-1896
Sylwia Magdalena BerusInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 01-224, Poland.ORCID http://orcid.org/0000-0003-1321-3884
Mateusz PielachInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 01-224, Poland.ORCID http://orcid.org/0000-0002-6849-1980
Paweł ŁagunaDepartment and Clinic of Oncology, Pediatric Hematology, Clinical Transplantology and Pediatrics, Medical University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0002-3656-5236
Aneta Aniela KowalskaInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 01-224, Poland.ORCID http://orcid.org/0000-0002-1904-9459
Agnieszka KamińskaInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 01-224, Poland. akaminska@ichf.edu.pl.ORCID http://orcid.org/0000-0002-1713-4182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The applicability of enhanced Raman spectroscopy (SERS) to differentiate acute lymphoblastic leukemia (ALL) in pediatric patients using clinically accessible biofluids remains unexplored. Therefore, this study addresses the need for a rapid, noninvasive method capable of distinguishing ALL from healthy conditions at the molecular level. Label-free SERS spectra obtained from bone marrow and blood plasma were analyzed using multivariate statistical methods supported by partial least squares regression, enabling discrimination between leukemia and healthy samples across three consecutive factors, which is 69%, 76% (X matrix), and 89%, 76% (Y matrix) for bone marrow and blood plasma, respectively. Moreover, the data calculated for blood plasma taken at diagnosis, consolidation, and control points explain 76% (X-matrix) and 66% (Y-matrix) of the total information. The corresponding weighted regression coefficients indicate that the variables at 653, 685, 724, 1002, and 1394 cm

Indexed as

Biomarkers, TumorBone MarrowPrecursor Cell Lymphoblastic Leukemia-LymphomaSpectrum Analysis, RamanChildChild, PreschoolFemaleHumansLeast-Squares AnalysisMaleBiomarkers, TumorAcute lymphoblastic leukemiaChemometric analysisLabel-free cancer detectionPediatric acute lymphoblastic leukemiaSurface-enhanced Raman Spectroscopy

Identifiers

PMID42618682
PMCPMC13490211

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.