Evidence map›Paper›PMID 42619690›Full record

ArticlebioRxiv : the preprint server for biology2026

Progranulin deficiency perturbs lipid metabolism in white matter microglia.

Dahyun Yu, Ellen Armour, Sonnet Davis, Jung Suh, Matthew Simon, Jimei Tong, Gilbert Di Paolo, Leonard Petrucelli

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dahyun YuDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Ellen ArmourDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Sonnet DavisDenali Therapeutics, South San Franscisco, California, United States of America.
Jung SuhDenali Therapeutics, South San Franscisco, California, United States of America.
Matthew SimonDenali Therapeutics, South San Franscisco, California, United States of America.
Jimei TongDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Gilbert Di PaoloDenali Therapeutics, South San Franscisco, California, United States of America.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.ORCID 0000-0003-2959-129X

Funding

Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLDR01NS132330 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Keith A Josephs, LEONARD PETRUCELLI · 2023 to 2026
$4.3M
Expanding insights into FTD disease mechanismsR35NS137447 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEONARD PETRUCELLI · 2025 to 2026
$2.3M
NINDS NIH HHS R01 NS132330NINDS NIH HHS R35 NS137447
6 · The paper itself

Abstract

Progranulin (PGRN) deficiency is a common hallmark in frontotemporal dementia (FTD) patients with granulin (

Identifiers

PMID42619690
PMCPMC13483875

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.