GPER in murine astrocytes and mural cells promotes neurovascular coupling and Aβ clearance.

Mengjiao Xu, Ke Chen, Meimei Wu, Huashan Gong, Ping Luo, Jing Wang, Weifang Rong

Abstract readPreprint

In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengjiao XuDepartment of Gastroenterology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.

Ke ChenDepartment of Gastroenterology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.

Meimei WuDepartment of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Huashan GongDepartment of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Ping LuoDepartment of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Jing WangDepartment of Gastroenterology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.

Weifang RongDepartment of Gastroenterology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) affects aged women more than men. The precipitous drop in sex hormone levels in postmenopausal women likely contributes to such sexual dimorphism, with emerging evidence implicating the G protein-coupled estrogen receptor (GPER) as a modulator of AD pathology and cognitive impairments. However, the underlying mechanism remains unknown. GPER is distinctively expressed in key components of the neurovascular unit (NVU), namely astrocytes and mural cells (specifically, pericytes). Using GPER-knockout (GPER-KO) and APP/PS1 transgenic AD mouse models, here we show that GPER deficiency exacerbates Aβ deposition, impairs spatial and working memory, and disrupts neurovascular coupling. GPER activation in pericytes reinforces

Indexed as

Alzheimer’s diseaseastrocytesAβ clearanceglymphatic systemGPERmural cellsneurovascular unitsexual dimorphism

Identifiers

PMID42619878

DOI10.21203/rs.3.rs-10359258/v1

PMCPMC13484409

What Socratic holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.