ArticleResearch square2026
Effects on cognition of regional astrogliosis assessed by
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Background: Increased peripheral inflammation and astrogliosis, as assessed by glial fibrillary acidic protein (GFAP) associates with worse cognition. GFAP, however, does not provide brain spatial information. Methods: In a sample of older adults without dementia, we evaluated the relationship of astrogliosis with overall and domain-specific cognitive performance (verbal memory, visual memory, executive function and attention). Results: Ninety-four non-demented participants were included (mean age: 68 ± 7 yrs, 52% women, 89%, White); among them, 76 were classified as A- and 18 as A+. Conclusion: In this non-demented population of older adults with low levels of Aβ pathology and neuroinflammation, astrogliosis related with worse cognitive functions, but only among A+ individuals. Further, IGFR1 may play a suppressive role decreasing by more than 50% the effect of astrogliosis on worse visual memory.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.