ArticleResearch square2026
APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies.
Estrella Morenas Rodríguez, Pablo Zaragoza-Ballester, Daniel Alcolea, Diana Esteller-Gauxax, Brigitte Nuscher, Sara Chacón, Álex Fernández-León, Íñigo Rodríguez-Baz, Alexandre Bejanin, Elena Vera and 11 more
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In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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5 · Who and what moneyAuthors and funding
21 authors.
Estrella Morenas RodríguezInstituto de Investigación Hospital 12 de Octubre.
Diana Esteller-GauxaxAlzheimer's disease and other cognitive disorders Unit. Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS. Department of Medic.
Brigitte NuscherLudwig-Maximilians-University Munich.
Sara ChacónHospital Universitario 12 de Octubre (Imas12) Research Institute.
Álex Fernández-LeónHospital de la Santa Creu i Sant Pau.
Íñigo Rodríguez-BazSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Sant Pau (IR SANT PAU).ORCID 0000-0003-3039-9115 Elena VeraHospital de la Santa Creu i Sant Pau.
Maria Franquesa-MulleratSant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Isabel Sala-MateveraHospital de la Santa Creu i Sant Pau.
Adolfo Gómez-GrandeHospital Universitario 12 de Octubre.
Mircea BalasaAlzheimer's disease and other cognitive disorders Unit. Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS. Centro de Investiga.ORCID 0000-0002-1795-4228 Juan ForteaSant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau-Universitat Autònoma de Barcelona.ORCID 0000-0002-1340-638X Funding
The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-RevisionRF1AG056850 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSCIGLIO, JORGE A, CUELLO, A CLAUDIO · 2018 to 2020
$5.9MTau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4MBilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive AphasiaR01AG080470 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI Stephanie M Grasso · 2023 to 2026
$2.8MBiological Correlates of Alzheimer in Down Syndrome.R21AG056974 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2017 to 2018
$414kNIA NIH HHS R01 AG080470NIA NIH HHS R21 AG056974NIA NIH HHS RF1 AG056850NIA NIH HHS RF1 AG061566
6 · The paper itselfAbstract
Dementia with Lewy bodies (DLB) is characterized by marked biological heterogeneity, only partly explained by the frequent presence of Alzheimer's disease (AD) copathology. Whether microglial responses contribute to this heterogeneity and how they are modulated by APOE genotype remain poorly understood. Using a specific immunoassay targeting cleaved soluble TREM2 (sTREM2), we investigated TREM2-dependent microglial responses across two independent DLB cohorts (n = 129) with molecular biomarker profiling and longitudinal follow-up. sTREM2 showed stage-dependent associations with AD-related biomarkers, being associated with amyloid-related changes during prodromal DLB and predominantly to tau-related markers at dementia stage.
Indexed as
ADAPOEcognitive declineDLBmicroglianeurodegenerationsynucleinopathyTREM2
Identifiers
PMID42620051
PMCPMC13484399
What Socratic holds
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