Evidence map›Paper›PMID 42620241›Full record

ArticlebioRxiv : the preprint server for biology2026

AI semantics for biomedical data integration.

James McLaughlin, Aleix Puig-Barbe, Arwa Ibrahim, Diego Pava, Zoe May Pendlington, Nicolas Matentzoglu, Elliot Sollis, Amy Foreman, Robert Wilson, Federico Lopez Gomez and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

James McLaughlinEMBL-EBI, Hinxton, UK.ORCID 0000-0002-8361-2795
Aleix Puig-BarbeEMBL-EBI, Hinxton, UK.ORCID 0000-0001-6677-8489
Arwa IbrahimEMBL-EBI, Hinxton, UK.ORCID 0000-0001-6757-4744
Diego PavaQueen Mary University of London.ORCID 0000-0002-4418-5137
Zoe May PendlingtonEMBL-EBI, Hinxton, UK.ORCID 0000-0002-4071-8397
Nicolas MatentzogluSemanticly, Athens, Greece.ORCID 0000-0002-7356-1779
Elliot SollisEMBL-EBI, Hinxton, UK.ORCID 0000-0003-1322-388X
Amy ForemanEMBL-EBI, Hinxton, UK.ORCID 0000-0002-5742-5048
Robert WilsonEMBL-EBI, Hinxton, UK.ORCID 0000-0002-9407-5526
Federico Lopez GomezEMBL-EBI, Hinxton, UK.ORCID 0000-0002-7138-3542
Laura HarrisEMBL-EBI, Hinxton, UK.ORCID 0000-0003-4312-7223
Yeyejide AdeleyeSyngenta Jealott's Hill International Research Centre, Bracknell RG42 6EY, U.K.
Satwant KaurData Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Birgit MeldalPfizer UK, Walton Oaks, Dorking Road, Tadworth, Surrey, KT20 7NS.ORCID 0000-0003-4062-6158
Damian SmedleyQueen Mary University of London.ORCID 0000-0002-5836-9850
Helen ParkinsonEMBL-EBI, Hinxton, UK.ORCID 0000-0003-3035-4195

Funding

Mouse Phenotyping Informatics Infrastructure - MP12UM1HG006370 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Pilar Cacheiro Martinez, Helen Elizabeth Parkinson · 2016 to 2026
$20.4M
The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
Improvements to the LinkML framework to support the Phenomics First open science resourceRM1HG010860 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2020 to 2024
$10.3M
3D Multiscale Biomolecular Human Reference Atlas Construction, Visualization and Usage [4 of 5]OT2OD033756 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI BORNER, KATY · 2022 to 2025
$7.4M
Strengthening community knowledge bases for genetic association studies and polygenic scores, the GWAS and PGS CatalogsU24HG012542 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Michael Inouye, Helen Elizabeth Parkinson · 2022 to 2026
$5.2M
NHGRI NIH HHS RM1 HG010860NHGRI NIH HHS U24 HG012542NHGRI NIH HHS UM1 HG006370NIH HHS OT2 OD033756NIH HHS R24 OD011883
6 · The paper itself

Abstract

Researchers increasingly need to explore hypotheses that span multimodal data across different scales, organisms, and domains. In practice, this requires connecting knowledge across fragmented databases with incompatible APIs and heterogeneous annotation practices. Large language model (LLM) agents can automate this data integration process, but grounding LLM agent outputs in scientifically correct sources of truth remains a significant challenge. Here we describe our deployment of a novel AI semantics workflow using LLM agents to enable scalable data integration, grounded in biological knowledge in the form of ontologies. Our workflow comprises (1) a multi-agent system curating scientific knowledge across ontologies using the Ontology Lookup Service (OLS) as grounding; (2) an LLM embedding service to enable interoperability between scientific databases by mapping ontology terms; and (3) GrEBI, a knowledge graph and Model Context Protocol (MCP) server enabling LLM agents to conduct cross-cutting, multi-omic biomedical queries.

Identifiers

PMID42620241
PMCPMC13484675

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.