ArticleiScience2026
Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact of
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Network-based discovery of regulatory drivers of cognitive decline in alzheimer's disease.npj aging · 2026Article
- Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson's disease.Research square · 2026Article
- Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brain.bioRxiv : the preprint server for biology · 2026Article
- RNA-seq variants reveal distinct patterns in the aging epitranscriptome: an in-depth analysis of age-matched Alzheimer's Disease patients and a cognitively normal cohort.bioRxiv : the preprint server for biology · 2026Article
- P2RX7 modulates the function of human microglia-like cells and mediates the association of IL18 with Alzheimer's disease traits.Neurobiology of disease · 2025Article
- TPClust: Temporal Profile-Guided Subtyping Using High-Dimensional Omics Data.bioRxiv : the preprint server for biology · 2025Article
- Dysregulation of Inositol Polyphosphate 5-Phosphatase OCRL in Alzheimer's Disease: Implications for Autophagy Dysfunction.International journal of molecular sciences · 2025Article
- Alternative production of pro-death Bax∆2 protein via ribosomal frameshift in Alzheimer's disease.Scientific reports · 2024Article
- Article
- Elucidating Multimodal Imaging Patterns in Accelerated Brain Aging: Heterogeneity through a Discriminant Analysis Approach Using the UK Biobank Dataset.Bioengineering (Basel, Switzerland) · 2024Article
- Unconventional Source of Neurotoxic Protein Aggregation from Organelle Off-Target Bax∆2 in Alzheimer's Disease.Biomolecules · 2023Article
- Effects of copy number variations on longevity in late-onset Alzheimer's disease patients: insights from a causality network analysis.Frontiers in aging neuroscience · 2023Article
- RNASE6 is a novel modifier of APOE-ε4 effects on cognition.Neurobiology of aging · 2022Article
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10 authors.
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Abstract
The heterogeneity of the aging population suggests the existence of molecularly distinct subgroups that differ in vulnerability to Alzheimer's disease (AD), yet this population structure remains poorly defined. We performed unsupervised clustering of multi-region brain transcriptomes to assess whether integrating data across regions involved in cognition could uncover such subgroups. Canonical correlation-based analysis in a discovery cohort of 459 participants with RNA-sequencing data from three regions (dorsolateral prefrontal cortex, posterior cingulate cortex, and anterior caudate), followed by replication in 690 additional participants with partial data, identified two meta-clusters (MC-1 and MC-2). These groups differed in cognitive trajectories, with MC-2 showing a three-year delay in dementia onset relative to MC-1. This may reflect, in part, a greater impact of tau pathology on neuronal chromatin architecture, white matter loss, and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.