ArticleFrontiers in medicine2026
Association between pregnancy cumulative glycemic exposure and postpartum glucose metabolism outcomes at 4-7 years: a cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: This study aimed to investigate the association between cumulative glycemic exposure (CGE) during pregnancy and glycemic metabolism abnormality (GMA) at 4-7 years postpartum and to compare its predictive value with that of a single fasting blood glucose (FBG) measurement. Methods: In this retrospective-prospective cohort study, 120 pregnant women were included from an existing cohort. CGE was calculated using the trapezoidal rule, and subjects were categorized into tertiles. A logistic regression analysis evaluated the association between CGE and GMA, and restricted cubic splines were used to evaluate dose-response relationships. The interaction between CGE and pre-pregnancy body mass index (BMI) was examined. Predictive performance was compared using receiver operating characteristic (ROC) curves. Results: Higher CGE was associated with an increased incidence of GMA [tertile 1 (T1): 10.0%, T2: 35.0%, T3: 65.0%]. Each 1-unit increment in CGE independently increased GMA risk (odds ratio = 1.040, 95% confidence interval: 1.01-1.07, Conclusion: CGE during pregnancy is an independent predictor of postpartum GMA. In clinical practice, adding pre-pregnancy BMI improves risk stratification, supporting the early identification of high-risk women. Clinical trial registration: Identifier ChiCTR2300067592.
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