Evidence map›Paper›PMID 42620965›Full record

ArticleKidney international reports2026

Causal Effects of Early Discontinuation of Proton Pump Inhibitors on Kidney Failure.

Yuki Kawano, Tatsufumi Oka, Yusuke Sakaguchi, Hikaru Kadono, Ryuta Uwatoko, Shungo Fukuda, Yohei Doi, Nobuhiro Hashimoto, Yasuo Kusunoki, Satoko Yamamoto and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuki KawanoDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Tatsufumi OkaDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Yusuke SakaguchiDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Hikaru KadonoDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Ryuta UwatokoDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Shungo FukudaDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Yohei DoiDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Nobuhiro HashimotoDepartment of Kidney Disease and Hypertension, Osaka General Medical Center, Osaka, Japan.
Yasuo KusunokiDepartment of Nephrology, Toyonaka Municipal Hospital, Toyonaka, Japan.
Satoko YamamotoDepartment of Nephrology, Ikeda City Hospital, Ikeda, Japan.
Masafumi YamatoDepartment of Nephrology, Sakai City Medical Center, Sakai, Japan.
Ryohei YamamotoDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Isao MatsuiDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Masayuki MizuiDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Jun-Ya KaimoriDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Yoshitaka IsakaDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Proton pump inhibitors (PPIs) are associated with adverse kidney outcomes. In clinical practice, however, long-term PPI use without a clear indication is common. It remains unclear whether discontinuing PPIs reduces the risk of kidney failure in patients who initiate PPIs. Using a target trial emulation approach, we estimated the causal effects of initiation and discontinuation of PPIs on the risk of kidney failure. Methods: Using data from the Osaka Consortium for Kidney Disease Research, a retrospective multicenter cohort in Japan, we emulated 2 target trials in patients with nondialyzed chronic kidney disease (CKD). First, we compared the risk of kidney failure with replacement therapy (KFRT) between PPI use and histamine Results: We identified 3512 PPI new users (76.1%) and 1102 H Conclusion: Discontinuing PPIs within 90 days after initiation was associated with better kidney outcome.

Indexed as

chronic kidney diseasekidney failure with replacement therapyproton pump inhibitor

Identifiers

PMID42620965
PMCPMC13487617

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.