Multi-omics-guided HAMA/PLMA bioink integrating mechanical support, antibacterial protection, and liposomal kartogenin for cartilage regeneration.

Tengfei Ma, Peixuan Wu, Yongning Sheng, Lian Duan, Jie Pei, Yanxin Liu, Kun Fu, Zeyu Liu

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Tengfei MaDepartment of Joint Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, China.

Peixuan WuKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou, 570228, China.

Yongning ShengDepartment of Joint Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, China.

Lian DuanDepartment of Comprehensive Surgery, Hainan Public Health Clinical Center, Haikou, 570203, China.

Jie PeiDepartment of Surgery, Haikou People's Hospital, Haikou, 570208, China.

Yanxin LiuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, United States.

Kun FuDepartment of Joint Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, China.

Zeyu LiuCenter for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Berlin, 13353, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Articular cartilage regeneration requires a bioink that combines printability with mechanical support, antibacterial functionality, and pro-chondrogenic bioactivity. Here, a 3D-printable hyaluronic acid methacrylate/polylysine methacrylamide (HAMA/PLMA, HP) hybrid hydrogel incorporating kartogenin-loaded liposomes (KGN@Lipo) was developed for articular cartilage regeneration. Integrated transcriptomic and metabolomic profiling identified HP-associated signatures related to ECM interaction and mechanotransduction, and selected mechanosensitive genes were subsequently validated by qRT-PCR. A second multi-omics comparison showed that KGN@Lipo@HP was associated with attenuated inflammatory-catabolic signaling and a matrix-protective cellular state relative to the Control condition. Physicochemical characterization confirmed rapid photocuring, reliable print fidelity, improved compressive behavior, cyclic resilience, and a tunable porous architecture, while liposomal loading preserved the optimized mechanical baseline. Functionally, KGN@Lipo@HP maintained high cytocompatibility, showed lower intracellular ROS-associated fluorescence, markedly inhibited

Indexed as

3D-printed bioinkAntibacterial protectionArticular cartilage regenerationHAMA/PLMA hybrid hydrogelMechanotransduction

Identifiers

PMID42621163

DOI10.1016/j.mtbio.2026.103546

PMCPMC13486536

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.