ArticleFrontiers in immunology2026
Time-resolved multi-omics reveals macrophage-centered immunometabolic remodeling in cutaneous dematiaceous fungal infection.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dematiaceous fungi cause chronic, invasive cutaneous infections that are difficult to eradicate and frequently relapse despite antifungal therapy. Although host immunity is critical for controlling these infections, the temporal organization of immune responses and the underlying immunometabolic programs remain poorly defined. In particular, how macrophage dynamics and chemokine signaling shape antifungal immunity over time is largely unknown. Methods: Using Results: Time-resolved multi-omics analysis revealed that days 7-14 post-infection constituted a critical transition phase of the host immune response, coinciding with lesion regression and pathogen clearance. This stage featured marked activation of pathways governing antigen presentation, phagosome formation and inflammatory signaling. Macrophages underwent dynamic changes in both abundance and phenotype during this period, accompanied by the upregulation of glycolysis- and lactate metabolism-related pathways. Co-expression and interaction network analysis further identified Conclusions: This study elucidates the dynamic remodeling of immunometabolism centered on macrophages during
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