ArticlePediatric transplantation2026
Influenza Disease Burden and Vaccine Effectiveness in Children and Adolescents With Solid Organ Transplant: 2018-2024.
Article in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSolid organ transplant (SOT) recipients have an increased risk of influenza infection. Annual vaccination is the primary strategy to reduce the burden of influenza disease, but vaccine effectiveness (VE) varies annually for influenza. There is limited data published demonstrating influenza VE in pediatric SOT over time.
methodsWe conducted a retrospective, case-control study using a test-negative design to estimate influenza VE against laboratory-confirmed influenza infections among pediatric SOT recipients aged 6 months to 21 years at two large pediatric transplant centers, spanning the six influenza seasons from fall 2018 through spring 2024. Logistic regression models were used to compare odds ratios (ORs) of vaccination in cases to controls. VE was calculated as [100% × (1 - adjusted OR)], and 95% confidence intervals (CIs) were computed around the estimates.
resultsAcross all 6 seasons, there were 4 585 patient encounters, of which 961 had an influenza test and were included in the study. Overall, 750 (78.0%) patients received the seasonal influenza vaccine, and 94 (9.9%) tested positive for influenza. Among vaccinated patients, the prevalence of influenza diagnosis was lower (6.8%) than among unvaccinated patients (20.4%) (OR 0.28, 95% CI 0.18-0.43). The adjusted VE against laboratory-confirmed influenza infection was 72.0% (95% CI 57.0-82.0) and varied by season. VE was similar between organ groups: Kidney (65.9%, 95% CI 29.7-83.4), heart (86.4%, 95% CI 59.0-95.5), and liver (71.7%, 95% CI 41.6-86.3).
conclusionsInfluenza vaccination decreased the risk of influenza infection among pediatric SOT recipients for the 2018-2024 influenza seasons.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.