ReviewCureus2026
Pre- and Post-treatment Changes in Systemic Inflammatory Biomarkers After Oral Appliance Therapy for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammation often accompanies obstructive sleep apnea (OSA), along with higher chances of heart-related metabolic issues. Although oral appliances serve as an accepted option instead of continuous positive airway pressure (CPAP), their influence on markers of systemic inflammation lacks clear evidence. The aim of this systematic review and meta-analysis was to assess changes in systemic inflammation markers following oral appliance therapy (OAT) among individuals diagnosed with OSA. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards, a systematic review and meta-analysis was conducted. Databases such as PubMed, Embase, Scopus, Web of Science, and Cochrane Library were examined. Studies assessing inflammatory markers before and after therapy among adults with OSA undergoing OAT formed part of the selection. For pooling results, reliance was made upon a random-effects framework. The present research was registered in PROSPERO with the ID CRD420261340212. From a total of 1,974 records screened, six studies qualified for inclusion in the qualitative analysis; among them, two contributed data for each outcome assessed through meta-analysis. Despite pooling outcomes across trials, no meaningful changes emerged in tumor necrosis factor-alpha levels (p = 0.536), nor in C-reactive protein (p = 0.061), or interleukin-6 concentrations (p = 0.230). Consistency between study findings showed minimal variation (I² = 0%). Despite improved clinical results in OSA, OAT shows minor impact on markers of systemic inflammation. To confirm these findings, broader trials with rigorous and uniform designs are needed.
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