Evidence map›Paper›PMID 42622716›Full record

ReviewCurrent hypertension reports2026

Parental Obesity and Offspring Risk for Cardiorenal Diseases.

Jussara M do Carmo, John E Hall, Zhen Wang, Alan J Mouton, Ana C M Omoto, Luciana Jorge, Alexandre A da Silva

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current hypertension reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jussara M do CarmoDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA. jdocarmo@umc.edu.
John E HallDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.
Zhen WangDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.
Alan J MoutonDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.
Ana C M OmotoDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.
Luciana JorgeDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.
Alexandre A da SilvaDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Cardiac protective mechanisms of melanocortin system activationR01HL163076 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jussara M. Do Carmo, Alexandre Alves da Silva · 2023 to 2026
$2.3M
Brain MC4R-BAT-Heart crosstalk: a potential new therapeutic target for myocardial ischemia/reperfusion injuryR01HL181254 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ana Carolina Mieko Omoto · 2025 to 2026
$1.1M
Long-term consequences of parental obesity on developmental programming of cardiorenal diseases in offspringR01DK121411 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI DO CARMO, JUSSARA M. · 2019 to 2021
$818k
AHA 26RIRA1643871NHLBI NIH HHS R01 HL155737NHLBI NIH HHS R01 HL163076NHLBI NIH HHS R01 HL181254NIDDK NIH HHS R01 DK121411NIGMS NIH HHS P30 GM149404NIGMS NIH HHS U54 GM115428NIH P30 GM149404, U54 GM115428NIH R01 DK121411, R01 HL163076
6 · The paper itself

Abstract

purpose of reviewObesity rates have increased dramatically during the past four decades, and these increases have occurred in children and adolescents, as well as in adults at reproductive age. Currently, 40.3% of men and 39.7% of women 20-39 years of age in the United States are classified as obese, leading to a substantial rise in parental obesity. Obesity is a major risk factor for cardiovascular, metabolic and renal diseases, including hypertension, type 2 diabetes, and chronic kidney diseases. This review examines current evidence of how parental obesity programs offspring susceptibility to cardiorenal and metabolic dysfunction and discusses the potential underlying mechanisms that contribute to the long-term health consequences in the offspring. RECENT

findingsIncreasing evidence indicates that parental obesity, particularly maternal obesity, predisposes offspring to cardiovascular, metabolic, and renal dysfunction that can emerge early in life and persist into adulthood, even when controlled for lifestyle factors. Although alterations in the intrauterine and early postnatal environments are believed to underlie developmental programming, the mechanisms by which parental obesity influences long-term offspring health remain poorly understood. Emerging evidence suggests that dysregulation of neurohumoral pathways, chronic inflammation, mitochondrial dysfunction, and intercellular signaling may be transmitted across generations and contribute to increased risk of cardiorenal and metabolic diseases. Elucidating these mechanisms is essential for identifying novel therapeutic targets and determining whether interventions implemented before conception, during pregnancy, or during early life can mitigate adverse health outcomes and improve long-term offspring health.

Indexed as

Cardiovascular DiseasesKidney DiseasesObesityPregnancy in ObesityPrenatal Exposure Delayed EffectsRenal Insufficiency, ChronicDevelopmental Origins of Health and DiseaseFemaleHumansPregnancyRisk FactorsAcute kidney injuryCardiovascular diseasesChronic kidney diseaseDevelopment programmingHeart failureMetabolic syndromeMyocardial infarction

Identifiers

PMID42622716
PMCPMC13493479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.