SynthesisSchizophrenia bulletin2026
Exploring the Relationship between Cognitive Performance, Performance-Based Functioning, and Everyday Functioning in People with Schizophrenia: a Systematic Literature Review.
Synthesis in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
background and hypothesisCognitive and functional impairments are core features of schizophrenia with considerable disease burden. However, the relationships between cognitive performance, functional capacity, and real-world functioning remain incompletely understood. This systematic review aimed to clarify the magnitude and nature of these interrelationships across primary research studies. STUDY
designA systematic review (PROSPERO CRD42024532729) was conducted across MEDLINE, Embase, PsycINFO, and Cochrane Database. Eligible articles assessed cognitive performance, functional capacity, and real-world functioning in adults with schizophrenia using standard psychometric instruments, and reported quantitative relationships between ≥1 of these constructs. Due to substantial heterogeneity in study designs, outcome measures, and reported metrics, a narrative synthesis was performed. STUDY
resultsOverall, 104 articles with unique datasets were included (88 observational, 16 interventional). The relationship between cognitive performance and functional capacity was the most studied (63/104 articles; 60.5%), with predominantly medium-to-large effect sizes. In contrast, associations between cognitive performance and real-world functioning were less frequently reported (43/104 articles, 41.3%) and largely small-to-medium, with only 2 large effect sizes identified. Associations between functional capacity and real-world functioning were variable (41/104 articles; 39.4%) and predominantly small-to-medium, with only 4 large effect sizes reported. Associations were less consistent when examined at the level of specific cognitive or functional domain.
conclusionsThis review highlights the central role of cognition in shaping functional abilities, while reinforcing the complexity of translating these gains into meaningful improvements in everyday functioning. A multimodal, person-centered approach is needed to effectively translate cognitive improvements into meaningful real-world outcomes in people with schizophrenia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.