ArticleJournal of acquired immune deficiency syndromes (1999)2026
Association of under-reporting of alcohol use with HIV viral non-suppression and an all-cause mortality risk score among people with HIV on antiretroviral therapy.
Article in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
17 authors.
Funding
Abstract
backgroundUnhealthy alcohol use contributes to poor HIV-related outcomes. Alcohol under-reporting may be associated with HIV viral non-suppression and all-cause mortality risk, especially at the high end of the spectrum. We evaluated whether alcohol under-reporting was associated with these outcomes among PWH with unhealthy alcohol use who were receiving ART.
methodsWe pooled data from six studies of PWH in Uganda (ADEPT-T, DIPT, Extend), United States (MWCCS), and Russia (Russia ARCH 1, St Peter). We included PWH on ART who engaged in unhealthy drinking as determined by the alcohol biomarker phosphatidylethanol (PEth)≥50ng/mL. Self-reported alcohol use was assessed using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). We defined under-reporting of high-risk alcohol use as PEth≥200ng/mL and AUDIT-C score<6, and examined HIV viral non-suppression (≥200copies/mL or limit of assay detection) and an all-cause mortality risk score (Veterans Aging Cohort Study [VACS] Index 1.0) as outcomes. We explored level of -under-reporting of alcohol use using a continuous variable.
resultsIn our sample of 1,435 PWH with unhealthy drinking, 24% under-reported high-risk alcohol use (prevalence range 1-34% across studies). We observed positive, non-significant associations between under-reporting of high-risk alcohol use and viral non-suppression and all-cause mortality risk score. An exploratory continuous under-reporting variable was significantly positively associated with all-cause mortality risk.
conclusionsOur findings indicate that under-reporting of high-risk alcohol use is common among PWH and suggest that under-reporting of alcohol use may mask other health issues, as reflected by increased mortality index scores. Low-cost methods to improve alcohol use are needed.
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Registered trials
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