Evidence map›Paper›PMID 42625618›Full record

ArticleFrontiers in nutrition2026

Effect of high-dose intravenous vitamin C on organ support-free days within the first 14 days in severe acute pancreatitis patients: a multicenter, randomized, double-blind, placebo-controlled clinical trial protocol.

Bing Zhao, Xianxian Yu, Haibo Zhang, Meiling Yu, Wenwu Sun, Fengying Zhao, Hua Huang, Menglong Song, Shu Wang, Wenjie Ma and 21 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06897384 (High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06897384 naactive not recruitingnot on this map

High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis

TypeinterventionalSponsorRuijin HospitalRan2025 to 2027Enrolled388ConditionsSevere Acute PancreatitisArmsSaline (NaCl 0,9 %), Vitamin C (Ascorbic Acid)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Bing Zhao *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xianxian Yu *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haibo Zhang *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Meiling Yu *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenwu Sun *Department of Emergency, Medical Center of Trauma and War Injury, Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, China.
Fengying Zhao *Department of Critical Care Unit, The Second People's Hospital of Chengdu, Sichuan University, Chengdu, Sichuan, China.
Hua Huang *Department of Critical Care Unit, Guanghan People's Hospital, Deyang, Sichuan, China.
Menglong Song *Department of Emergency Intensive Care Unit, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Shu Wang *Department of Intensive Care Medicine, Chongqing University Central Hospital (Chongqing Emergency Medical Center), Chongqing, China.
Wenjie Ma *Department of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.
Meihua ShenNational Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, China.
Shuyuan ZhaoDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yihui WangDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Menglu GuiDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dan XuDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengqi GaoDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huiqiu ShengDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li MaDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weisong JiangDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ning NingDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Silei SunDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang LiDepartment of Emergency, Medical Center of Trauma and War Injury, Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, China.
Qionghua HuDepartment of Critical Care Unit, The Second People's Hospital of Chengdu, Sichuan University, Chengdu, Sichuan, China.
Xiaojiao LiuDepartment of Critical Care Unit, Guanghan People's Hospital, Deyang, Sichuan, China.
Ping ZhouDepartment of Emergency Intensive Care Unit, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Yang TaoDepartment of Intensive Care Medicine, Chongqing University Central Hospital (Chongqing Emergency Medical Center), Chongqing, China.
Jun HuangDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yue ZengDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Meitang WangDepartment of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.
Ruilan WangDepartment of Emergency and Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Enqiang MaoDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The global incidence of severe acute pancreatitis (SAP) is increasing, yet mortality rates remain persistently high. Novel therapeutic approaches are urgently needed to improve outcomes. The aim of this study is to evaluate the efficacy of high-dose intravenous vitamin C in improving organ support-free days within the first 14 days and other clinical outcomes in patients with SAP. Method: This is a prospective, randomized, double-blind, multicenter clinical trial. Participants will be stratified and randomly assigned to either the HDIVC group or the control group. Data will be analyzed using SAS 9.4 with two-sided tests and a significance threshold of Discussion: If proven effective, the results of this trial could establish high-dose intravenous vitamin C as a cost-effective adjunctive therapy to improve survival in patients with severe acute pancreatitis and potentially inform future clinical practice guidelines. Clinical trial registration: ClinicalTrials.gov, identifier NCT06897384.

Indexed as

high-dose intravenous vitamin Cintensive care unitmulticenterrandomized controlled trialsevere acute pancreatitis

Identifiers

PMID42625618
PMCPMC13489861

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.