Evidence map›Paper›PMID 42626268›Full record

ArticleWorld journal of nephrology2026

Curcumin attenuates high glucose-induced apoptosis in renal tubular epithelial cells by enhancing the Nrf2/heme oxygenase-1 antioxidant pathway.

Yu Li, Lu-Lu Wang, Xiang-Zhi Yu, Sai Xie, Peng-Fei Li, Yang Huang, Pei-Ling Bao

Abstract read
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Article in World journal of nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu LiDepartment of Nephrology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China.
Lu-Lu WangDepartment of Nephrology, Wuhan University of Science and Technology School of Medicine, Wuhan 430000, Hubei Province, China.
Xiang-Zhi YuDepartment of Nephrology, Wuhan University of Science and Technology School of Medicine, Wuhan 430000, Hubei Province, China.
Sai XieDepartment of Nephrology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China.
Peng-Fei LiDepartment of Cardiovascular Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China.
Yang HuangDepartment of Nephrology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China.
Pei-Ling BaoDepartment of Nephrology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China. bpltg2023@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic nephropathy (DN) is a major complication that arises from diabetes. Curcumin, a bioactive compound with antioxidant properties, has been shown to modulate multiple cellular pathways and thereby mitigate tissue damage.

aimTo explore the influence of curcumin on high glucose-triggered apoptosis in renal tubular epithelial cells.

methodsSprague-Dawley rats were divided into control, diabetic, and curcumin treatment groups (

resultsCurcumin improved renal function markers and reduced renal tubular apoptosis in diabetic rats.

conclusionCurcumin protects against high glucose-induced renal tubular epithelial apoptosis by enhancing Nrf2/HO-1 signaling to reduce oxidative stress and apoptosis, indicating its therapeutic potential for DN.

Indexed as

ApoptosisCurcuminNrf2/heme oxygenase-1 signaling pathwayOxidative stressRenal tubular epithelial cells

Identifiers

PMID42626268
PMCPMC13491208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.