ArticlePain reports2026
Ultraviolet-B sensitizes silent nociceptors and desensitizes C-touch fibers to slow depolarizing electrical stimuli in pigs.
Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Tetrodotoxin-resistant voltage-sensitive sodium channel subtypes 1.8 and 1.9 play a key role on "silent" (mechano-insensitive) nociceptors activation during sinusoidal electrical stimulation. Therefore, we hypothesized that an UVB-induced sensitization of this particular nociceptor class can be revealed by such electrical stimulation pattern. Objectives: We set out to study ultraviolet-B (UV-B)-induced sensitization of C-nociceptors using heat and mechanical stimulation, but also transduction independent slow depolarizing electrical pulses. Methods: Single fibre recordings of pig saphenous nerve were performed after UV-B irradiation with 3-fold minimum erythemal doses. Results: A total 45 C fibers were recorded from UV-B inflamed skin and discharge patterns compared with nonirradiated control units (n = 134). We did not observe a sensitization to heat or mechanical stimulation in mechanosensitive nociceptors, but some of the "silent" nociceptors were sensitized to mechanical stimulation. The most drastic changes were found for electrical activation thresholds that increased about 3-fold in tactile "C-touch" fibers, but that were reduced in silent nociceptors up to a factor of 5. The threshold to 1-Hz stimulation was also increased 2-fold in "polymodal" nociceptors, although not significantly. Conclusion: Potentially, the combination of desensitized C-touch and polymodal nociceptors with sensitized silent nociceptors might be based on high expression of depolarization-resistant Na
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