ArticleClinical pharmacology and therapeutics2026
Characteristics of Severe and Typical Agranulocytosis Induced by Antithyroid Drugs.
Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Agranulocytosis is a rare but serious side effect of antithyroid drugs (ATDs), defined by an absolute neutrophil count (ANC) below 500/μL; some patients develop a more severe form with ANC below 100/μL. We retrospectively compared the clinical, biochemical, and HLA-B allele profiles between the two presentations in 24 cases of ATD-induced agranulocytosis. Based on nadir ANC, 15 participants with ANC < 100/μL formed the severe group and 9 with ANC 100-500/μL comprised the typical group. The severe group had a significantly longer neutrophil recovery time (5 [5-7] vs. 3 [2.5-3.5] days; P = 0.003), higher median levels of total bilirubin (21.4 [13.3-30.4] vs. 7.1 [6.2-18.3] μmol/L; P = 0.003) and indirect bilirubin (9.9 [7.6-16.7] vs. 6.1 [3.6-9.8] μmol/L; P = 0.018), and fewer asymptomatic patients at presentation (0/15 vs. 5/9, P = 0.003). HLA typing confirmed that HLA-B*38:02 was associated with severe ATD-induced agranulocytosis (OR = 48.6; 95% CI = 2.3-1020.7; P = 5.9 × 10
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