Evidence map›Paper›PMID 42627471›Full record

ReviewAmerican journal of clinical dermatology2026

Cutaneous Aging in Skin of Color: A Narrative Review.

Nisal Vipulaguna, Ferdos Abdulkader, Eryn Patin, Saroja Rao, Nada Elbuluk, Arianne Shadi Kourosh, Tasneem F Mohammad, Michelle Rodrigues

Abstract readReview
PubMed Publisher
In one paragraph

Review in American journal of clinical dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nisal VipulagunaThe University of Queensland Faculty of Medicine, Brisbane, QLD, Australia.ORCID http://orcid.org/0009-0002-9857-774X
Ferdos AbdulkaderDepartment of Dermatology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0009-0005-9080-4487
Eryn PatinUniversity of Texas Southwestern Medical School, Dallas, TX, USA.
Saroja RaoDepartment of Dermatology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0005-5113-939X
Nada ElbulukDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5956-4404
Arianne Shadi KouroshDepartment of Dermatology, Beth Israel, Deaconess Medical Center, Boston, MA, USA.
Tasneem F MohammadDepartment of Dermatology, Henry Ford Health, Detroit, MI, USA.ORCID http://orcid.org/0000-0002-1374-1815
Michelle RodriguesThe University of Melbourne, Melbourne, VIC, Australia. michelle.rodrigues@unimelb.edu.au.ORCID http://orcid.org/0000-0002-9747-1882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous aging is a complex biological process that follows a distinct trajectory in skin of color (Fitzpatrick skin types III-VI) compared with lighter skin types. While increased epidermal melanin provides partial photoprotection and often delays the development of rhytides, skin of color is disproportionately affected by pigmentary sequelae of aging, including mottled hyperpigmentation, solar lentigines, melasma, and post-inflammatory hyperpigmentation. These differences are further complicated by gaps in skin of color-specific clinical training, as well as heterogeneity across ethnic subtypes, cultural practices, and social determinants, making management of aging in skin of color uniquely challenging. In this narrative review, we summarize contemporary evidence on the clinical and histologic features of skin of color, key mechanisms underlying intrinsic aging and photoaging, and practical strategies to address common aging concerns in this population. We highlight that long-wavelength UVA (UVA1) and visible light can induce oxidative stress and persistent pigmentation, and that conventional sunscreens may inadequately protect against these wavelengths. Accordingly, broad-spectrum photoprotection, particularly formulations that provide visible-light coverage (e.g., tinted sunscreens with iron oxides), should be emphasized as a cornerstone intervention. We also review topical agents (including retinoids and pigment modulators), oral antioxidants, and procedural therapies, underscoring the need for cautious selection and technique given the higher propensity for post-inflammatory hyperpigmentation and scarring. These strategies are underpinned by the need for individualized counseling, culturally responsive education, and improved skin of color-specific training for dermatologists globally.

Identifiers

PMID42627471

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.