ArticleProbiotics and antimicrobial proteins2026
Antimicrobial Peptides Improved Growth Performance by Intervening Ileac Microorganisms and Metabolites in Holstein Steers.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The use of antibiotics as feed additives has promoted the emergence of antimicrobial resistance, thereby increasing the morbidity and mortality associated with infections that were previously treatable. Antimicrobial peptides (AMP) have appeared as a promising strategy in replacing antibiotics in ruminant production. However, there are few reports on the effects of AMP on the ileal function, microorganisms and metabolites in Holstein steers. In this study, Eighteen Holstein steers were split randomly into two groups (n = 9). The control group (CON) was fed a basic diet, and antimicrobial peptide group (AMP) was fed basic diet supplemented with 8 g/(d·head) of AMP for 270 days. AMP significantly improved ileac volatile fatty acids (VFA), such as propionate (P ≤ 0.05), and the ileal absorptive surface area - villus height (VH, P ≤ 0.05). Thereby enhanced growth performance of steers (P ≤ 0.05), including final body weight (FBW), average daily gain (ADG) and carcass weight (CW). And then, we reported and supplemented the profiles of the ileac microorganisms and metabolites of Holstein cattle using metagenomics and metabolomics. AMP reduced both virus abundance and Clostridium growth, and increased the microbial abundance in ileum of steers; Turicibacter sanguinis and Clostridium perfringens were dominant microorganisms in AMP and CON group, respectively. LPE, Hyodeoxycholic acid and Hyodeoxycholic acid effected the growth and health of steers. KEGG analysis revealed that AMP improved growth by upregulating ileac amino acid and carbohydrate metabolism. Spearman analysis indicates key microorganisms and metabolites interacted with each other and promoted the growth and health of steers. These findings provide essential insights into the molecular mechanisms in effect of AMP on ileac microorganisms and metabolites of steers, which suggested its potential application as a dietary additive to improved growth and health in steers.
Indexed as
Identifiers
42627596What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.