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ArticleAbdominal radiology (New York)2026

The fascial involvement score retains diagnostic value for complicated appendicitis on CT when specific signs are absent.

Lei Wu, Wei-Xian You, Ling-Hong Wang, Xiao-Fei Zhang, Qiu-Yi Lu, Xiao-Yu Chen, Xu-Ping Mao

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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Lei WuZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.
Wei-Xian YouZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.
Ling-Hong WangZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.
Xiao-Fei ZhangZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.
Qiu-Yi LuZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.
Xiao-Yu ChenZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China. 631923927@qq.com.
Xu-Ping MaoZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China. maoxupingpaper@163.com.

Funding

Jiangsu Medical Vocational College Campus Collaborative Innovation Research Project 20239604Jiangsu Medical Vocational College Campus Collaborative Innovation Research Project 202490616National Mentorship Program for Health Youth Backbone Talent in Suzhou Qngg2024035Suzhou Medical Association 'Radiology Star' General Scientific Research Project 2025YX-M06Suzhou Science and Technology for Youths for Promoting Health through Science and Education Project KJXW2023064
6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic performance of the fascial involvement score in predicting complicated appendicitis among patients without extraluminal air, extraluminal appendicolith, or abscess on CT.

methodsThis single-center retrospective study initially included 307 patients with surgically and/or pathologically confirmed appendicitis who underwent unenhanced CT and lacked the three specific CT signs of complicated appendicitis. Of these, 287 patients had assessable fascial structures and formed the primary analytic sample for the fascial involvement score. The fascial involvement score, appendiceal diameter, and laboratory markers were assessed. Multivariate logistic regression and ROC analyses were performed to identify independent predictors of complicated appendicitis.

resultsOf the 307 patients, 120 (39.1%) had complicated appendicitis. The fascial involvement score (OR: 1.673; 95% CI 1.285-2.178), appendiceal diameter (OR: 1.163; 95% CI 1.033-1.309), and C-reactive protein (CRP) level (OR: 1.011; 95% CI 1.005-1.016) were independent predictors of complicated appendicitis. The optimal cutoff for the fascial involvement score was 1.5 (AUC: 0.699). Combining the fascial involvement score with CRP (≥ 24.1 mg/L) achieved a numerically higher AUC (0.702) compared with other combinations, with a specificity of 81.3% and a sensitivity of 59.2%.

conclusionThe fascial involvement score is a useful adjunctive CT marker for identifying complicated appendicitis even in the absence of overt imaging signs. Combining it with CRP enhances diagnostic specificity and may guide timely surgical intervention.

Indexed as

Acute appendicitisComplicated appendicitisComputed tomographyC-reactive proteinFascial involvement score

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.