Evidence map›Paper›PMID 42629471›Full record

SynthesisEndocrine pathology2026

Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas.

Anna-Maria Wiejak, Georgiana Constantinescu, Gintare Zygiene, Mercedes Robledo, Christian G Ziegler, Jens-Peter Kühn, Ronald de Krijger, Christina Pamporaki, Matthias Meinhardt, Nicole Bechmann

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Endocrine pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna-Maria WiejakDepartment of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Georgiana ConstantinescuDepartment of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Gintare ZygieneInstitute for Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Mercedes RobledoHereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Christian G ZieglerDepartment of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Jens-Peter KühnInstitute and Policlinic for Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Ronald de KrijgerPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Christina PamporakiDepartment of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Matthias MeinhardtDepartment of Pathology, Faculty of Medicine Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Technical University Dresden, Dresden, Dresden, Germany.
Nicole BechmannInstitute for Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Nicole.bechmann@uniklinikum-dresden.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paragangliomas (PGLs) are rare neural crest-derived tumors with highly variable morphology and clinical behavior. These tumors can present with cystic and necrotic alterations that may influence the clinical presentation of affected patients. However, prevalence and clinical significance of these pathological alterations remain poorly understood. In this retrospective study (2011-2021), 103 patients with confirmed PGLs were examined for cystic and necrotic alterations based on imaging and pathology reports as well as pathological re-evaluation. Cystic alterations, including microscopic, macroscopic, and pseudocystic alterations, were observed in 61.8% of PGLs. Regardless of their pathomorphological presentation, cystic alterations did not affect the clinical presentation of these patients. In contrast, necrotic alterations were identified in 3.9% of PGLs and were associated with a higher rate of metastasis (75% vs. 10%, p = 0.0124), larger tumor volume (53.6 cm

Indexed as

Cardiovascular DiseasesParagangliomaAdultAgedCystsFemaleHumansMaleMiddle AgedNecrosisNeoplasm MetastasisRetrospective StudiesCardiovascular complicationsHemorrhagic alterationsMetastasisNecrosisNeuroendocrine tumorsPreoperative management

Identifiers

PMID42629471
PMCPMC13498522

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.