ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
The effects of bariatric surgery on dementia in patients with diabetes and obesity.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionType 2 diabetes (T2D) and obesity are among the most important risk factors for dementia. Although weight loss is an important preventive strategy, the impact of metabolic and bariatric surgery (MBS) on dementia risk remains contradictory.
methodsWe conducted a propensity score matched study using nationwide, high-quality clinical registries to compare the outcomes in patients with obesity and T2D who underwent MBS with matched controls who did not undergo surgery.
resultsOver a mean follow-up of 9 years, MBS was associated with a reduced risk of dementia (15-year cumulative incidence 1.8% vs. 2.7%, subdistribution hazard ratio [SHR] 0.60, 95% CI 0.47-0.76). The incidence was lower for Alzheimer's disease (1.2% vs. 1.9%, SHR 0.56, 95% CI 0.41-0.76) and vascular dementia (0.4% vs. 0.7%, SHR 0.49, 95% CI 0.29-0.85), but increased for alcohol-related dementia (0.2% vs. 0.04%, SHR 3.67, 95%CI 1.33-10.14). DISCUSSION: These findings suggest that the collected long-term effects of MBS may reduce the risk of developing dementia in individuals with obesity and T2D.
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