Evidence map›Paper›PMID 42630954›Full record

ArticleACS bio & med chem Au2026

Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD.

Collin E Merrick, Ketan D Patel, Parismita Kalita, Nicole Gulati, Andrew M Gulick, Timothy A Wencewicz

Abstract read
In one paragraph

Article in ACS bio & med chem Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Collin E MerrickDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID https://orcid.org/0009-0009-5728-4749
Ketan D PatelDepartment of Structural Biology, Jacobs School of Medicine & Biomedical Sciences at the University at Buffalo, Buffalo, New York 14203, United States.
Parismita KalitaDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Nicole GulatiDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.
Andrew M GulickDepartment of Structural Biology, Jacobs School of Medicine & Biomedical Sciences at the University at Buffalo, Buffalo, New York 14203, United States.ORCID https://orcid.org/0000-0003-4238-7453
Timothy A WencewiczDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID https://orcid.org/0000-0002-5839-6672

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
Structural Studies of Nonribosomal Peptide SynthesisR35GM136235 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GULICK, ANDREW M · 2020 to 2024
$2.0M
Antibiotic-based PET Imaging of Implant Associated Gram-positive Bacterial InfectionsR21EB034882 · NIBIB · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2024 to 2024
$385k
NIBIB NIH HHS R21 EB034882NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R35 GM136235
6 · The paper itself

Abstract

Under iron limiting conditions, bacteria biosynthesize and secrete small molecule iron chelators, siderophores, to scavenge this essential metal. Siderophores are biosynthesized by nonribosomal peptide synthetases (NRPS) or NRPS independent siderophore (NIS) synthetases, the latter of which are significantly less studied.

Indexed as

desferrioxaminesenzyme inhibitorsenzyme mechanismnatural product biosynthesisNIS synthetasesiderophoreStreptomyces

Identifiers

PMID42630954
PMCPMC13495013

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.