Evidence map›Paper›PMID 42630988›Full record

ArticleiScience2026

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.

Mingling Ding, Xiaoxiao Li, Yuchao Wei, Jitong Wang, Bohan Jiao, Caiyue Li, Wenbo Ma, Yongbo Peng, Jinhua Shen, Guanghui Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingling DingCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Xiaoxiao LiCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Yuchao WeiCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Jitong WangCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Bohan JiaoCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Caiyue LiThe Eighth Affiliated Hospital of Southern Medical University, Foshan, Guangdong 528300, China.
Wenbo MaThe Eighth Affiliated Hospital of Southern Medical University, Foshan, Guangdong 528300, China.
Yongbo PengCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Jinhua ShenCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Guanghui YuHubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.
Chao GaoCollege of Life Sciences, South-Central Minzu University, Wuhan, Hubei 430074, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-2 cells and murine UUO and aging models. Integrating

Indexed as

chronic kidney diseasefibrosisinflammationretatrutidesemaglutidetirzepatide

Identifiers

PMID42630988
PMCPMC13495082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.