Evidence map›Paper›PMID 42631071›Full record

ArticleACS measurement science au2026

Label-Free SERS Analysis of Glioma Cells to Detect Drug Resistance Using Metabolic Phenylalanine Level.

Guohui Yang, Xin Wang, Jingbin Jin, Xiaozhang Qu, Kaizhi Zhang, Shuping Xu

Abstract read
In one paragraph

Article in ACS measurement science au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guohui YangChina-Japan Union Hospital of Jilin University, Changchun 130033, PR China.
Xin WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
Jingbin JinChina-Japan Union Hospital of Jilin University, Changchun 130033, PR China.
Xiaozhang QuThe First Hospital of Jilin University, Changchun 130031, PR China.
Kaizhi ZhangChina-Japan Union Hospital of Jilin University, Changchun 130033, PR China.
Shuping XuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.ORCID https://orcid.org/0000-0002-6216-6175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is one of the most common malignant brain tumors, and its mainstream clinical treatment regimens mainly include postoperative combined with Temozolomide chemotherapy. Unfortunately, glioma cells tend to mutate when subjected to prolonged Temozolomide treatment, leading to drug resistance and significantly weakening the therapeutic effect. Delaying the resistance time of Temozolomide has become a pressing issue for clinicians to address, and the primary regimen for delaying drug resistance is the combined application of Temozolomide with other therapies. To explore new molecular diagnostic markers of drug resistance in glioma and to assess treatment stage, surface-enhanced Raman spectroscopy (SERS) was used to investigate changes in glioma cells under combined therapies including physical (electrical stimulation, ES) and chemical (cancer drug: Temozolomide) treatments. By analyzing intensity changes in the SERS band at 997 cm

Indexed as

Electrical stimulationLabel-freePheSERSTemozolomide

Identifiers

PMID42631071
PMCPMC13495487

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.