Evidence map›Paper›PMID 42631327›Full record

ArticleJournal of drug delivery science and technology2025

Balanced enhancement of antibacterial activity and biocompatibility in chitosan-vancomycin 3D-printed scaffolds through mesoporous bioactive glass addition.

Amir Parvinnasab, Sahar Rostami, Ashkan Namdar, Erfan Salahinejad, Amir Hossein Taghvaei, Shaghayegh Abdi, Sarah Rajabi, Lobat Tayebi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug delivery science and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amir ParvinnasabFaculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Sahar RostamiFaculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Ashkan NamdarFaculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Erfan SalahinejadFaculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Amir Hossein TaghvaeiDepartment of Materials Science and Engineering, Shiraz University of Technology, Shiraz, Iran.
Shaghayegh AbdiDepartment of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Sarah RajabiDepartment of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI 53233, USA.

Funding

Synthetic osteo-odonto-keratoprosthesis (OOKP, Tooth-in-Eye surgery)R21EY035480 · NEI · MARQUETTE UNIVERSITY · PI TAYEBI, LOBAT · 2023 to 2024
$634k
Vascularization of critical-sized craniomaxillofacial defectsR56DE029191 · NIDCR · MARQUETTE UNIVERSITY · PI TAYEBI, LOBAT · 2021 to 2021
$363k
NEI NIH HHS R21 EY035480NIDCR NIH HHS R56 DE029191
6 · The paper itself

Abstract

The rising incidence of osteomyelitis and growing challenges associated with conventional antibiotic therapy underscore an urgent need for novel therapeutic interventions. This study explores the development and characterization of chitosan/vancomycin/mesoporous bioactive glass (Chi-Van-MBG) 3D-printed scaffolds incorporating various MBG/Chi ratios, aimed at enhancing the viability and proliferation of human bone marrow mesenchymal stem cells (hBMSCs) along with antibacterial effectiveness. Preliminary analyses, including the assessment of chemical composition, morphology, swelling, and degradation behaviors, demonstrated promising characteristics for bone tissue engineering applications. The scaffolds also exhibited an initial burst release of vancomycin, followed by a sustained release over four weeks, ensuring effective antibacterial potency. Notably, a considerable inhibition zone of 40 mm against

Indexed as

3D printingBacterial infectionBiocompatibilityBiofilmTissue regeneration

Identifiers

PMID42631327
PMCPMC13498394

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.