ArticleJournal of food science2026
Evaluation of the Neuroprotective Effects of Diospyros discolor and Diospyros ebenum Leaf Bioactive Fractions In Vivo and Their UPLC-ESI-MS/MS Chemical Characterization: A Comparative Study.
Article in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Species of Diospyros L. genus (Ebenaceae family) are known for their economic, nutritional, and pharmacological values. This study aimed to compare the neuroprotective effects of Diospyros discolor and Diospyros ebenum against dementia, with reference to their phytochemical composition. Chemical composition of both species was unveiled through ultra-performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-ESI-MS/MS). Promising fractions of both species were standardized against the major identified active constituent(s) via high-performance liquid chromatography-photodiode array detector (HPLC-PDA). Both Diospyros species were evaluated for their neuroprotective activity in vivo using scopolamine-induced dementia in animal model. UPLC-ESI-MS/MS of the EtOAc fractions of D. discolor and D. ebenum resulted in identification of 14 and 48 compounds, respectively, which belong to different classes, namely, organic acids, phenolics, naphthoquinones, triterpenoids, and sterols. Gallic acid contents in EtOAc fractions of D. discolor and D. ebenum were 295.95 and 1.5 µg/mg fraction, respectively. In elevated plus-maze (EPM) test, a tendency towards reduction in the inflexion ratio (IR) was noticed in scopolamine-injected group, however, groups treated with EtOAc fractions of D. discolor, D. ebenum, and pure gallic acid displayed a counteraction pattern. In novel object recognition (NOR) test, tested groups showed the same discrimination index. In brain histological study, treated groups with D. discolor, D. ebenum, and pure gallic acid revealed amelioration compared to scopolamine. In alignment, both EtOAc fractions and gallic acid counteracted the scopolamine-induced dementia in rats and significantly lowered the levels of acetylcholinesterase. Thus, Diospyros species demonstrated a significant ameliorative effect on neurotoxicity induced by scopolamine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.