ArticleJournal of neurology2026
Subjective sleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in multiple sclerosis.
Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveSleep modulates brain-fluid transport and glymphatic clearance. In multiple sclerosis (MS), lower diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index has been reported, but whether sleep quality contributes to DTI-ALPS variability is unknown. We assessed whether sleep disturbances are associated with a lower DTI-ALPS index in MS.
methods77 MS patients and 84 age- and sex-matched healthy controls (HC) underwent 3 T brain MRI. In MS patients, disability was assessed with the expanded disability status scale (EDSS), sleep quality with the Pittsburgh sleep quality index (PSQI; >5 defining sleep disturbances), and fatigue with the modified fatigue impact scale (MFIS). DTI-ALPS index was derived from fractional anisotropy (FA) maps after lesion exclusion.
resultsSleep disturbances were reported in 32 (41.6%) MS patients. Disease duration, clinical phenotype, treatment status, and EDSS score did not differ between patients with and without sleep disturbances (p ≥ 0.181). Compared with HC, both MS groups showed a higher T2-hyperintense lesion volume, a lower brain volume, a lower FA and a higher mean diffusivity in normal-appearing white matter, and a lower DTI-ALPS index (p-FDR≤0.007). DTI-ALPS index was lower in patients with sleep disturbances than those without (p-FDR=0.029), with no differences in other MRI variables. In MS patients, a higher PSQI score was associated with a lower DTI-ALPS index (r=-0.356, p-FDR=0.003) and a higher MFIS score (r=0.461, p-FDR<0.001), but not with conventional MRI measures (p-FDR≥0.189).
conclusionsSleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in MS, independent of clinical disability and conventional MRI measures. Sleep quality should be considered when interpreting DTI-ALPS measures in MS.
Indexed as
Identifiers
42631758What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.