Evidence map›Paper›PMID 42632528›Full record

ArticleCellular signalling2026

Phosphoglycerate mutase 5 regulates lipid metabolism and mitochondrial homeostasis in hepatocellular cancer cells.

Praveen Kumar Guttula, Ganesan Muthusamy, Chin-Chi Liu, Priscilla Devora, Emi Sasaki, Tyler Butsch, Hasand Gandhi, James Moran, Manas Ranjan Gartia, Andrea N Johnston

Abstract read
PubMed Publisher
In one paragraph

Article in Cellular signalling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2026
5 · Who and what money

Authors and funding

10 authors.

Praveen Kumar GuttulaDepartment of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Ganesan MuthusamyDepartment of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Chin-Chi LiuOffice of Research and Graduate Education, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA.
Priscilla DevoraDepartment of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Emi SasakiLouisiana Animal Disease Diagnostic Laboratory and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
Tyler ButschDepartment of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Hasand GandhiDepartment of Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
James MoranDepartment of Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Manas Ranjan GartiaDepartment of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Andrea N JohnstonDepartment of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA. Electronic address: john8926@msu.edu.

Funding

Strategic inhibition of EGFR-family signaling using novel peptidomimetic inhibitors of HER-2 for the treatment of osteosarcomaP20GM135000 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI CHAMCHEU, JEAN CHRISTOPHER · 2021 to 2025
$11.3M
Spatial metabolomics with subcellular resolution to identify therapeutic targetsR35GM150564 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Manas Ranjan Gartia · 2023 to 2026
$1.5M
NIGMS NIH HHS P20 GM135000NIGMS NIH HHS R35 GM150564
6 · The paper itself

Abstract

The mitochondrial membrane protein phosphoglycerate mutase 5 (PGAM5) is a protein of interest in the transition from hepatic steatosis to hepatocellular carcinoma. Increased expression of PGAM5 in hepatocellular carcinoma correlates with reduced patient survival. Herein we demonstrate that loss of PGAM5 promotes mitochondrial oxidant injury and suppresses the glycerophospholipid and lysophospholipid pathways, leading to accumulation of the bioactive phospholipid lysophosphatidylcholine. Additionally, PGAM5 deletion reduces diacylglycerol concentrations by attenuating long-chain fatty acid uptake and suppressing its synthesis. These findings underscore the broad impact of a single phosphatase on mitochondrial function and provide a rationale for therapeutically targeting PGAM5 in hepatocellular carcinoma.

Indexed as

Carcinoma, HepatocellularLipid MetabolismLiver NeoplasmsMitochondriaMitochondrial ProteinsPhosphoglycerate MutaseAnimalsCell Line, TumorDiglyceridesHomeostasisHumansLysophosphatidylcholinesPhosphoprotein PhosphatasesDiglyceridesLysophosphatidylcholinesMitochondrial ProteinsPGAM5 protein, humanPhosphoglycerate MutasePhosphoprotein PhosphatasesDiacylglycerolLysophosphatidylcholineMitochondrial metabolismSphingolipid

Identifiers

PMID42632528

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.