Evidence map›Paper›PMID 42632849›Full record

ArticleMolecular neurobiology2026

Reduction of Lipid Droplets Modulates the Injury Response and Enhances CNTF-Induced Axon Regeneration Following Optic Nerve Crush.

Xiaowei Fan, Ruyue Li, Shen Wu, Xuejing Yan, Yue Wan, Jingxue Zhang, Ningli Wang

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaowei FanBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, Capital Medical University, Beijing, China.
Ruyue LiDepartment of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Shen WuBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, Capital Medical University, Beijing, China.
Xuejing YanBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, Capital Medical University, Beijing, China.
Yue WanDepartment of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jingxue ZhangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, Capital Medical University, Beijing, China. jingxuezh@ccmu.edu.cn.
Ningli WangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, Capital Medical University, Beijing, China. wningli@vip.163.com.

Funding

NationaFoundationl Natural Science of China 82130029NationaFoundationl Natural Science of China 82301195
6 · The paper itself

Abstract

Disruption of lipid metabolism occurs in both the retina and optic nerve following optic nerve crush (ONC); however, whether the regulation of lipid droplets (LDs) influences the survival and function of retinal ganglion cells (RGCs) remains largely elusive. Here, we identified the distribution of LDs in the retina and optic nerve of ONC mice, and A922500, a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), was applied to investigate the effect of suppressing LD biogenesis on RGC survival and visual function. The results showed that LDs were localized in Tuj1-positive cells within the retina and in IBA1-positive cells within GFAP-negative region of optic nerve following injury. A922500 significantly reduced LD accumulation and attenuated microglial density in both retina and optic nerve, but did not affect RGC survival following injury. No regenerating CTB-labeled axons were observed with A922500 monotherapy. However, combined treatment with A922500 and AAV2-CNTF enhanced axon regeneration compared to CNTF-treated alone. A922500 also significantly improved flash visual evoked potential recordings in both ONC control mice and CNTF-treated mice after injury. This study demonstrates that optic nerve crush induces LD accumulation in retinal RGC somas and in microglia at the optic nerve injury site, and reducing LDs does not preserve RGC survival but attenuates injury response, enhances CNTF-induced axon regeneration, and improves visual function.

Indexed as

AxonsCiliary Neurotrophic FactorLipid DropletsNerve CrushNerve RegenerationOptic Nerve InjuriesAnimalsCell SurvivalMaleMice, Inbred C57BLMicrogliaOptic NerveRetinal Ganglion CellsCiliary Neurotrophic FactorAxon regenerationLipid dropletsMicrogliaOptic nerve crushRetinal ganglion cell

Identifiers

PMID42632849

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.