Evidence map›Paper›PMID 42633152›Full record

ArticleGastro hep advances2026

Fiber-Dependent Microbiome Glycine Lipids Ameliorate Steatotic Liver Disease in Mice via Mitochondrial Enhancement.

Liya Anto, Lidan Gao, Jaeeun Lee, Chelsea Garcia, Oliver Otoko, Emma Hickey, Neha Mishra, Siyun Kim, Sung Gi Noh, Mi-Bo Kim and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Liya AntoDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Lidan GaoDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Jaeeun LeeDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Chelsea GarciaDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Oliver OtokoDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Emma HickeyDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Neha MishraDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut.
Siyun KimDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Sung Gi NohDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Mi-Bo KimDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Hyunju KangSchool of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
Saki MihoriDepartment of Immunology, UConn Health, Farmington, Connecticut.
Saurav RanjitkarDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Alison B KohanDepartment of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania.
Young-Ki ParkDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Anthony A ProvatasCenter for Environmental Sciences and Engineering, University of Connecticut, Storrs, Connecticut.
Clinton MathiasDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Oh Sung KwonDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Robert B ClarkDepartment of Immunology, UConn Health, Farmington, Connecticut.
Ji-Young LeeDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.
Frank C NicholsDepartment of Periodontology, UConn Health, Farmington, Connecticut.
Christopher N BlessoDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Oral and gut Methods: Microbiome-derived GLs were quantified in murine systemic and portal blood, intestinal lymph, and in mouse and human liver using targeted mass spectrometry. Their biological effects were assessed in mouse and cell culture models of diet-induced liver disease following treatment with L654- and L1256-enriched lipid extracts. Results: L654 and L1256 species were detected in mouse serum, portal plasma, intestinal lymph, and liver, as well as in human liver tissue. A Western-type high-fat diet lowered fecal and hepatic microbiome GLs, whereas fermentable fiber supplementation restored fecal levels (∼7-fold increase), with hepatic GL content showing an inverse association with liver triglycerides. In a 22-week diet-induced MASLD model, administration of L654- or L1256-enriched lipids for 8 weeks significantly reduced hepatic steatosis and histopathological progression. Treatments enhanced mitochondrial DNA content and metabolic function in liver and HepG2 cells. L1256 increased hepatic triggering receptor expressed on myeloid cells 2 expression, associated with lipid sensing and MASLD protection, while L654 modulated splenic cluster of differentiation 4 Conclusion: Microbiome-derived GLs are diet-sensitive molecules that protect against MASLD via mitochondrial enhancement, revealing a novel nutritional-microbial axis for liver disease intervention.

Indexed as

BacteriaInflammationNutrition

Identifiers

PMID42633152
PMCPMC13499107

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.