Evidence map›Paper›PMID 42633186›Full record

ArticleOsteoarthritis and cartilage open2026

Thigh muscle volume change is associated with longitudinal structural and functional knee osteoarthritis progression - Data from the osteoarthritis initiative.

Sevtap Tugce Ulas, Felix Liu, Gabby B Joseph, Sharmila Majumdar, Gabbie Hoyer, Michael C Nevitt, Charles E McCulloch, Nancy E Lane, Thomas M Link, Alexandra S Gersing

Abstract read
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In one paragraph

Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sevtap Tugce UlasDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Felix LiuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Gabby B JosephDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Gabbie HoyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Nancy E LaneDepartment of Medicine, University of California, Davis, CA, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Alexandra S GersingDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the association of change in thigh muscle volume (TMV) with structural knee changes and changes in knee pain and functional limitation over 48 months. Design: Deep learning-based automated segmentations were used to quantify magnetic resonance imaging-derived TMV at baseline and 48 months in 1715 participants from the Osteoarthritis Initiative (mean age 60.0 years; 54.3% women). Participants were categorized by quartile of percentage TMV change over 48 months into muscle loss (Q1: -29.8 to < -7.2%,n = 420), stable muscle (Q2+Q3: -7.2 to <2.4%,n = 864) and muscle gain group (Q4: 2.4-23.7%,n = 431). Structural knee changes were assessed using the Whole-Organ Magnetic Resonance Imaging Score (WORMS), changes in knee pain and functional limitations using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and physical function with the Repeated Chair Stand Test (CST). Associations between TMV changes, WORMS, and functional outcomes were analyzed using multivariable and ordinal regression models. Results: Over 48 months, muscle gain was significantly (p < 0.05) associated with less worsening of bone marrow edema-like lesions (β = -0.29 [95% confidence interval: -0.47, -0.10]), reduced worsening of ligamentous damage (β = -0.12 [-0.22, -0.02]), and less increase in WOMAC pain (β = -0.36 [-0.68, -0.04]) compared to the stable muscle group. Muscle loss was associated with greater tendon damage (β = 0.08 [0.01, 0.15]) and greater declines in CST (β = -0.58 [-1.08, -0.08]). No significant associations were observed between the muscle groups for cartilage and menisci WORMS progression or for physical function (p > 0.05). Conclusions: Thigh muscle gain was associated with less progression in ligamentous damage and bone marrow edema-like lesions and pain, whereas muscle loss was associated with greater tendon progression and decline in physical performance.

Indexed as

Deep learningMRIMusclesOsteoarthritis

Identifiers

PMID42633186
PMCPMC13499110

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.