Evidence map›Paper›PMID 42633216›Full record

ReviewBrain, behavior, & immunity - health2026

Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction.

Yadiel A Rivera-Lopez, Luinet L Melendez-Rodriguez, Orlando I Torres-Rodriguez, Luis M Rivera-Perez, Alanis P Torres-Rosado, Shelley S Tworoger, Guillermo N Armaiz-Pena

Abstract readReview
In one paragraph

Review in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yadiel A Rivera-LopezDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, United States.
Luinet L Melendez-RodriguezDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, United States.
Orlando I Torres-RodriguezDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, United States.
Luis M Rivera-PerezDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, United States.
Alanis P Torres-RosadoDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, United States.
Shelley S TworogerDivision of Oncological Sciences and Knight Cancer Institute, Oregon Health & Sciences University, Portland, OR, United States.
Guillermo N Armaiz-PenaDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, United States.

Funding

Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KENNETH Lynn WRIGHT · 2012 to 2026
$23.1M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Harold I Saavedra · 2012 to 2026
$23.0M
RISE Option III: Ponce School of Medicine MBRS-RISE ProgramR25GM082406 · NIGMS · PONCE SCHOOL OF MEDICINE · PI APPLEYARD, CAROLINE B · 2008 to 2021
$9.5M
The role of biobehavioral factors and anti-inflammatory medications on the ovarian tumor immune responseR01CA276224 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Guillermo N Armaiz-Pena, Shelley S Tworoger · 2023 to 2026
$2.0M
Adrenergic signaling inhibition to enhance the immunogenicity of the ovarian tumor microenvironment prior to PD-1 checkpoint therapyR21CA253555 · NCI · PONCE SCHOOL OF MEDICINE · PI ARMAIZ-PENA, GUILLEROMO N · 2020 to 2021
$523k
NCI NIH HHS R01 CA276224NCI NIH HHS R21 CA253555NCI NIH HHS U54 CA163068NCI NIH HHS U54 CA163071NIGMS NIH HHS R25 GM082406
6 · The paper itself

Abstract

Cancer progression is profoundly influenced by the complex interplay between the tumor microenvironment (TME), the immune system, and the patient's psychological state. This review delineates a critical pathway linking chronic stress to worsened cancer outcomes through inflammatory factors, anti-tumor immune suppression, and the induction of behavioral comorbidities. We postulate that sustained stress hormone signaling

Identifiers

PMID42633216
PMCPMC13499141

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.