Evidence map›Paper›PMID 42633304›Full record

ArticleClinical neurophysiology practice2026

Evolving epileptic activity under focal rhythmic Delta activity: insights from simultaneous intracranial and scalp EEG.

Ayumi Sakata, Nobutaka Mukae, Takafumi Shimogawa, Takahiko Mukaino, Kimiaki Hashiguchi, Kazuhisa Kuwabara, Kou Matsumoto, Takahiro Yamaguchi, Taira Uehara, Toshiki Okadome and 11 more

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Article in Clinical neurophysiology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Ayumi SakataDivision of Medical Technology, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nobutaka MukaeDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takafumi ShimogawaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takahiko MukainoDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kimiaki HashiguchiDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kazuhisa KuwabaraDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kou MatsumotoDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takahiro YamaguchiDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Taira UeharaDepartment of Neurology, Fukuoka Sanno Hospital, Fukuoka, Japan.
Toshiki OkadomeDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yasunari SakaiDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yuri SonodaDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Satoshi AkamineDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Pin Fee ChongDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kenta KajiwaraDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Eriko WatanabeDepartment of Clinical Laboratory, Kyushu University Hospital, Fukuoka, Japan.
Noriko IsobeDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koji YoshimotoDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takato MoriokaDepartment of Neurosurgery, Hachisuga Hospital, Munakata, Japan.
Yuya KunisakiDepartment of Clinical Laboratory, Kyushu University Hospital, Fukuoka, Japan.
Hiroshi ShigetoDivision of Medical Technology, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Focal rhythmic delta activity (RDA) is a subtype of lateralized RDA (LRDA). Although several studies have compared scalp and intracranial electroencephalography (EEG) recordings to determine whether LRDA observed on scalp EEG reflects epileptic abnormalities occurring intracranially during the acute phase, to our knowledge, no studies have examined focal RDA. Therefore, we investigated the extent to which focal RDA on scalp EEG during the acute phase reflects epileptic activity observed on intracranial EEG. Methods: We retrospectively reviewed cases with simultaneous intracranial and scalp EEG (January 2003-August 2024). Patients who developed an intracranial hematoma during electrode placement were identified and included. For each case, we evaluated whether RDA, spikes, polyspikes, electrographic seizures (ESz), electrographic status epilepticus (ESE), and high-frequency oscillations (HFOs) observed on intracranial EEG near the hematoma were reflected on scalp EEG in terms of appearance, timing, frequency, and amplitude. Results: Of the 116 patients, six developed intracranial hematoma and were included in the analysis. Focal RDA was observed on scalp EEG in all six cases, whereas intracranial RDA appeared earlier than focal RDA on scalp EEG. In all cases, spikes and polyspikes were superimposed on the RDA in the intracranial EEG, whereas these findings were observed on scalp EEG in only three cases. ESz, ESE, and HFOs were observed in all intracranial recordings but were not detected on scalp EEG. Significance: Focal RDA observed on scalp EEG during the acute phase may reflect growing epileptic activity and serve as a potential target for antiseizure medication therapy.

Indexed as

Electrographic seizuresElectrographic status epilepticusFocal rhythmic delta activityHigh-frequency oscillationIntracranial hematomaIntracranial recording

Identifiers

PMID42633304
PMCPMC13499354

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