ArticleEuropean oral research2026
Morphological and physicochemical impact of an experimental epigallocatechin-3-gallate based gel on erosive dentin wear.
Article in European oral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The aim of this study is to evaluate in vitro the morphological and physicochemical effects of an experimental epigallocatechin-3-gallate (EGCG) gel and its combination with sodium fluoride (NaF) on the progression of dentin erosion. Materials and Methods: Initial lesions were induced in bovine dentin samples (n=10/group) and divided into: Control (gel without active ingredients), NaF (1.23% NaF), EGCG (10% EGCG), and EGCG+NaF (10% EGCG + 1.23% NaF). Half of the sample was protected and the other half treated and subjected to erosive/abrasive challenges (0.3% citric acid, pH=2.6 and simulated brushing). Volume loss (VL) and surface roughness (Ra) were evaluated by 3D laser confocal microscopy. Dentin composition was analyzed by Raman spectroscopy, considering mineral/matrix ratio (MMR), collagen organization, and crystallinity. Results: The EGCG+NaF group presented the lowest VL values (p<0.05). The Control group had the highest MMR values, while the EGCG+NaF group presented the lowest (p<0.05). For the Amide I/III ratio, the Control group had the lowest values and the EGCG+NaF group the highest (p<0.05). No statistically significant differences among the groups regarding the crystallographic order (p= 0.668). Conclusion: The combination of EGCG and NaF demonstrates the ability to mitigate volume loss under erosive-abrasive challenges, preserve structural integrity, and enhance collagen cross-linking within the demineralized organic matrix of dentin.
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