Evidence map›Paper›PMID 42633908›Full record

ArticleLuminescence : the journal of biological and chemical luminescence2026

Photodynamic Therapy for Toxoplasma gondii Infections Using Rose Bengal.

Wen Li, Jiating Chen, Jie Li, Qingqing Zhang, Jihong Chen, Pengfei Zhang, Fufeng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Luminescence : the journal of biological and chemical luminescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen LiCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Jiating ChenGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID https://orcid.org/0000-0002-4312-3428
Jie LiBeijing Life and Science Academy, Beijing, China.
Qingqing ZhangStem Cell & Regenerative Medicine Consortium, School of Biomedical Sciences LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, China.ORCID https://orcid.org/0000-0003-4443-1331
Jihong ChenDepartment of Nephrology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0000-0002-1676-5732
Pengfei ZhangGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID https://orcid.org/0000-0003-0390-3806
Fufeng LiuCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.ORCID https://orcid.org/0000-0002-9454-2382

Funding

Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund 2023A1515220119High-level Medical Team Project in Baoan, Shenzhen 202401National Key Research and Development Program of China 2023YFC3605502National Natural Science Foundation of China 22574170National Natural Science Foundation of China 82470719Research Project on High-Quality Innovative Development of Medical-Education Collaboration YJXT20250401Shenzhen Science and Technology Program KQTD20210811090115019
6 · The paper itself

Abstract

Toxoplasma gondii is a globally prevalent obligate intracellular protozoan parasite that causes severe zoonotic disease. Given the limitations of conventional drug therapies, including susceptibility to drug resistance, and significant toxic side effects, this study aimed to evaluate the efficacy of photodynamic therapy (PDT) combined with the classic photosensitizer Rose Bengal in eradicating T. gondii tachyzoites, whilst elucidating its underlying mechanism of action. Experimental results demonstrate that Rose Bengal efficiently induces the generation of both Type I and Type II reactive oxygen species (ROS) under light exposure, exhibiting potent phototoxic killing effects against T. gondii. Further transcriptomic analysis revealed that this mechanism involves Rose Bengal disrupting metabolic and motility-related signaling pathways in T. gondii, thereby programmatically inducing T. gondii cell death. Both in vivo and in vitro experiments confirmed that this approach effectively eradicates T. gondii while demonstrating favorable biosafety. This study provides experimental evidence for developing novel photodynamic therapies against T. gondii, expanding the application potential of photodynamic therapy in combating parasitic infections.

Indexed as

PhotochemotherapyPhotosensitizing AgentsRose BengalToxoplasmaToxoplasmosisAnimalsMiceReactive Oxygen SpeciesPhotosensitizing AgentsReactive Oxygen SpeciesRose Bengalphotodynamic therapyreactive oxygen speciesRose BengalToxoplasma gondiitranscriptomic profiling

Identifiers

PMID42633908
PMCPMC13500219

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.