ArticleJournal of neurochemistry2026
Hippocampal Astrocytes Impact Postnatal Development of Inhibitory Connections, Parvalbumin Levels, Social, and Spatial Navigation Behaviors in a Mouse Model of Fragile X Syndrome.
Victoria A Wagner, Sarah Maples, Ritika Thapa, Jordan Wimberly, Ellie Pettijohn, Alexandra Varallo, Maham Rais, Samantha Sutley-Koury, Peter Hickmott, Iryna M Ethell
Abstract read
In one paragraphArticle in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Victoria A WagnerDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, University of California Riverside School of Medicine, Riverside, California, USA.
Jordan WimberlyDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, University of California Riverside School of Medicine, Riverside, California, USA.
Alexandra VaralloDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, University of California Riverside School of Medicine, Riverside, California, USA.ORCID https://orcid.org/0009-0002-4887-3348 Maham RaisDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, University of California Riverside School of Medicine, Riverside, California, USA.
Samantha Sutley-KouryDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, University of California Riverside School of Medicine, Riverside, California, USA.
Peter HickmottNeuroscience Graduate Program, University of California Riverside, Riverside, California, USA.
Funding
UC Riverside MARC U* Star Undergraduate Research ProgramT34GM062756 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MARTINEZ, ERNEST · 2001 to 2022
$8.7MMolecular and cellular mechanisms of inhibitory synapse developmentR01NS129555 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Iryna M Ethell · 2024 to 2026
$1.4MElucidating the Role of Astrocytic Ephrin-B1 in Inhibitory Circuit Development in the CA1 HippocampusF31NS129205 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SUTLEY-KOURY, SAMANTHA · 2022 to 2023
$79kCellular and molecular mechanisms of auditory processing deficits in a mouse model of Fragile X SyndromeF31NS117178 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI RAIS, MAHAM · 2020 to 2021
$56kCalifornia Institute for Regenerative Medicine EDUC4-12752NIGMS NIH HHS T34 GM062756NIH HHS T34GM062756NINDS NIH HHS F31 NS117178NINDS NIH HHS F31NS117178NINDS NIH HHS F31 NS129205NINDS NIH HHS F31NS129205NINDS NIH HHS NS129555NINDS NIH HHS R01 NS129555
6 · The paper itselfAbstract
Fragile X Syndrome (FXS) is a leading genetic cause of autism-like symptoms and intellectual disability, resulting from epigenetic silencing of the Fragile X messenger ribonucleoprotein (Fmr1) gene. Recent observations in FXS models suggest abnormal GABAergic signaling and excitation/inhibition imbalance may underlie the pathophysiology of FXS. As most studies have focused on neuronal mechanisms, the role of astrocytes in mediating defective inhibition in FXS is largely unknown. Our previous study showed the effects of astrocyte-specific Fmr1 conditional knockout (cKO) on cortical inhibitory circuit development using EEGs that were attributed to excess GABA synthesis by Fmr1 KO astrocytes. As the hippocampus plays an important role in spatial learning and social behaviors that are altered in FXS, in this study we focused on dissecting the mechanism of abnormal inhibition in the CA1 hippocampus using slice electrophysiology. While we observed a reduction in the expression of synaptic GABA
Indexed as
AstrocytesFragile X SyndromeHippocampusParvalbuminsSocial BehaviorSpatial NavigationAnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1Inhibitory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLMice, KnockoutNeural InhibitionFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1ParvalbuminsastrocytesautismFragile X syndromeGABA transporthippocampal circuitsneurodevelopmental disordersparvalbumin inhibitory interneuronssocial behaviorspatial navigationtonic inhibition
Identifiers
PMID42634176
PMCPMC13500873
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