Evidence map›Paper›PMID 42634354›Full record

ArticleBasic & clinical pharmacology & toxicology2026

The Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burden Among Hospitalised Older Patients.

Kinda Ibrahim, Eloise Radcliffe, Edward Hewertson, Andrew Bates, Andy Fox, Emily Smith, Cathrine Mckenzie, Liam Jones, Sara Mckelvie, Ngianga Ii Kandala and 3 more

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In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kinda IbrahimApplied Research Collaboration Wessex, National Institute of Health and Care Research (NIHR), University of Southampton, Southampton, UK.
Eloise RadcliffeSchool of Primary Care, Population Sciences and Medical Education, Primary Care Research Centre, University of Southampton, Southampton, UK.
Edward HewertsonMedicine for Older People Department, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Andrew BatesCritical Care and Perioperative theme, NIHR Southampton Biomedical Research Centre, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-3614-0270
Andy FoxPharmacy Department, NHS University Hospital Southampton, Southampton, UK.
Emily SmithPharmacy Department, NHS University Hospital Southampton, Southampton, UK.
Cathrine MckenzieCritical Care and Perioperative theme, NIHR Southampton Biomedical Research Centre, Faculty of Medicine, University of Southampton, Southampton, UK.
Liam JonesApplied Research Collaboration Wessex, National Institute of Health and Care Research (NIHR), University of Southampton, Southampton, UK.
Sara MckelvieApplied Research Collaboration Wessex, National Institute of Health and Care Research (NIHR), University of Southampton, Southampton, UK.
Ngianga Ii KandalaApplied Research Collaboration Wessex, National Institute of Health and Care Research (NIHR), University of Southampton, Southampton, UK.
Sara McCloskeySchool of Primary Care, Population Sciences and Medical Education, Primary Care Research Centre, University of Southampton, Southampton, UK.
Tracey SachSchool of Primary Care, Population Sciences and Medical Education, Primary Care Research Centre, University of Southampton, Southampton, UK.
Stephen LimApplied Research Collaboration Wessex, National Institute of Health and Care Research (NIHR), University of Southampton, Southampton, UK.

Funding

National Institute for Health and Care Research Applied Research Collaboration (ARC) Wessex
6 · The paper itself

Abstract

introduction37%-48% of older patients receive anticholinergic medicines, increasing the risk for falls, delirium, dementia and death. Hospital admission may provide an opportunity for deprescribing to improve outcomes. This study evaluated the feasibility and acceptability of a digital tool to identify anticholinergic medicines and support deprescribing.

methodsA pre-post feasibility study was conducted (May-September 2025). Patients aged ≥ 75 with an ACB score of ≥ 3, screened using a digital tool, were recruited. The identified medications were highlighted to the clinical team to prompt a medication review (stop, reduce or switch). Primary outcomes were recruitment and retention. Secondary outcomes included medication and patients' outcomes, healthcare use and acceptability from qualitative interviews.

resultsRecruitment was challenging; 65 out of 301 patients with ACB ≥ 3 (22%) were eligible, 21 participated, of which 15 (80%) completed follow-up. Mean age was 84.7 years, and intervention costs were £9.33 per patient. Interviews indicated technical and organisational challenges. Mean ACB scores were 3.85 (admission), 3.45 (discharge), 3.0 (1 month) and 3.44 (3 months), with slight changes in cognition and delirium but no changes in depressive symptoms or quality of life.

conclusionsAlthough acceptable, recruitment and technical challenges limited feasibility. Findings should be interpreted cautiously due to the small sample size, and further refinement is needed before implementation.

Indexed as

Cholinergic AntagonistsDeprescriptionsAgedAged, 80 and overDeliriumFeasibility StudiesFemaleHospitalizationHumansMaleCholinergic Antagonists

Identifiers

PMID42634354
PMCPMC13501056

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.