ReviewInternational journal of nanomedicine2026
Applications of Nanomaterials in Chronic Wound Healing and Scar Prevention.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds are difficult to heal due to pathological microenvironments characterized by persistent inflammation, oxidative stress, hypoxia, and biofilm infections; traditional therapies are unable to comprehensively address these issues. Nanomaterials, with their unique physicochemical properties, bring about a paradigm shift in treatment by regulating the wound microenvironment through multi-target mechanisms. This review comprehensively analyzes the latest advances in metallic, carbon-based, polymeric, and composite nanomaterials, focusing on how these materials effectively treat chronic wounds by scavenging reactive oxygen species, inducing the polarization of macrophages from the pro-inflammatory M1 to the reparative M2 phenotype, promoting angiogenesis, and enabling controlled drug release. Emerging stimulus-responsive nanoplatforms and composite systems can synergistically remove biofilms, reduce inflammation, and remodel the extracellular matrix, achieving the dual effects of accelerated healing and scar reduction. We also discuss challenges in translation, including biosafety, pharmacokinetics, and large-scale production, and propose future directions for integration with smart drug delivery, cell therapy, and gene editing. This review provides a theoretical basis and research guidance for utilizing nanotechnology to overcome barriers to chronic wound healing and prevent pathological scarring.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.