ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Risk factors and population attributable fraction for dementia in American Indians: The Strong Heart Study.
Astrid M Suchy-Dicey, Kristoffer Rhoads, Thomas Grabowski, Eric B Larson, Spero Manson, Dedra Buchwald, W T Longstreth
Abstract read
In one paragraphArticle in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Kristoffer RhoadsUniversity of Washington, Seattle, Washington, USA.
Thomas GrabowskiUniversity of Washington, Seattle, Washington, USA.
Eric B LarsonUniversity of Washington, Seattle, Washington, USA.
Spero MansonAnschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.
Dedra BuchwaldUniversity of Washington, Seattle, Washington, USA.
W T LongstrethUniversity of Washington, Seattle, Washington, USA.
Funding
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MThe Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2MSTRONG HEART STUDY (SHS): OUHSC COORDINATING CENTER - TASK AREA B (B.1 AND B.3)75N92019D00027 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, YING · 2019 to 2025
$15.5MCARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6MSTRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9MCARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9MSTRONG HEART STUDY (SHS)-MISSOURI BREAKS INDUSTRIES RESEARCH, INC.- FIELD CENTER (FC) TASK AREA B (B.1 AND B.3)75N92019D00029 · NHLBI · MISSOURI BREAKS RESEARCH, INC. · PI FRETTS, AMANDA MAE · 2019 to 2025
$7.5MCerebrovascular Disease and its Consequences in the Strong Study CohortR01HL093086 · NHLBI · WASHINGTON STATE UNIVERSITY · PI BUCHWALD, DEDRA S · 2009 to 2013
$7.3MSTRONG HEART STUDY (SHS)- UNIVERSITY OF OKLAHOMA-FIELD CENTER (FC), TASK AREA B.3, YEAR 375N92019D00028 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ALI, TAUQEER · 2019 to 2025
$6.5MSTRONG HEART STUDY (SHS)- MEDSTAR HEALTH RESEARCH INSTITUTE (MHRI) FIELD CENTER -SUBTASK AREA B.2 PHASE VII EXAM AND EXAM CLOSEOUT.75N92019D00030 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2019 to 2025
$5.2MCVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6MCARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3MNational Institutes of Health (NIH) 75N92019D00027National Institutes of Health (NIH) 75N92019D00028National Institutes of Health (NIH) 75N92019D00029National Institutes of Health (NIH) 75N92019D00030National Institutes of Health (NIH) K01AG057821National Institutes of Health (NIH) P50AG005136National Institutes of Health (NIH) R01AG070822National Institutes of Health (NIH) R01HL093086National Institutes of Health (NIH) R01HL109282National Institutes of Health (NIH) R01HL109284National Institutes of Health (NIH) R01HL109301National Institutes of Health (NIH) R01HL109315National Institutes of Health (NIH) R01HL109319National Institutes of Health (NIH) U01HL41642National Institutes of Health (NIH) U01HL41652National Institutes of Health (NIH) U01HL41654National Institutes of Health (NIH) U01HL65520National Institutes of Health (NIH) U01HL65521NHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS R01 HL093086NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIA NIH HHS K01 AG057821NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG070822
6 · The paper itselfAbstract
introductionPrevious works implicate 14 modifiable risk factors as underlying 45% of dementia cases. Population attributable fraction (PAF) is population-specific, limiting generalizability. Little is known about the risk and PAF of dementia in American Indians.
methodsAmerican Indians from the Southwest, Southern Plains, and Northern Plains made multiple visits from mid- to late-life (1989 to 2019). Cognitive status was adjudicated by panel consensus (ages 70 to 95). Logistic regression models assessed relative risk and PAF for dementia.
resultsAmerican Indians had distinctive patterns of factor prevalence. The proportion with limited education and social isolation was similar. Mid-life depression, head injury, smoking, hypertension, obesity, and diabetes were more common. High low-density lipoprotein levels, sedentary/inactivity, and consumption of ≥21 units of alcohol/week were less common. We did not assess hearing loss, vision loss, or air pollution. Significant risk factors for dementia with PAF percentage were as follows: education (19%), hypertension (11%), isolation (13%), and depression (60%). DISCUSSION: Important, unique risk patterns were detected for American Indians, in contrast to prior models.
Indexed as
American Indian or Alaska NativeDementiaIndians, North AmericanAgedAged, 80 and overDepressionFemaleHumansMalePrevalenceRisk FactorsAmerican IndiansdementiaepidemiologyNative Americanspopulation attributable fractionpopulation attributable risk
Identifiers
PMID42635108
PMCPMC13501501
What Socratic holds
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